Declaring the success of an unprecedented experiment in science and philanthropy, Los Angeles-based philanthropists Eli and Edythe ӳý announced today that they have increased their total gift to the ӳý of Harvard and MIT to $600 million. Adding to their previous gifts totaling $200 million, the ӳýs today gave an endowment of $400 million to convert the Institute, which had been launched as a 10-year “venture” experiment, into a permanent biomedical research organization aimed at transforming medicine.