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Hung Lab

Targeting virulence: a new paradigm for antimicrobial therapy.

Clatworthy AE, Pierson E, Hung DT. Targeting virulence: a new paradigm for antimicrobial therapy. Nat Chem Biol. 2007;3(9):541-8. doi:10.1038/nchembio.2007.24

Chemical biology and bacteria: not simply a matter of life or death.

Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol. 2006;10(4):321-6. doi:10.1016/j.cbpa.2006.06.016

Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization.

Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science. 2005;310(5748):670-4. doi:10.1126/science.1116739

Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner.

Hung DT, Mekalanos JJ. Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. Proc Natl Acad Sci U S A. 2005;102(8):3028-33. doi:10.1073/pnas.0409559102

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.

Hung DT, Chen J, Schreiber SL. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol. 1996;3(4):287-93.