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Brain Health

Pyramidal neurons proportionately alter cortical interneuron subtypes.

Wu SJ, Dai M, Yang SP, et al. Pyramidal neurons proportionately alter cortical interneuron subtypes. Nature. 2026. doi:10.1038/s41586-025-09996-8

Blocking RAN translation without altering repeat RNAs rescues -related ALS and FTD phenotypes.

Jiang X, Schaeffer L, Patni D, et al. Blocking RAN translation without altering repeat RNAs rescues -related ALS and FTD phenotypes. Science (New York, N.Y.). 2026;391(6785):eadv2600. doi:10.1126/science.adv2600

Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia.

Zhou T, Ho YY, Hartley ND, et al. Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia. Nature neuroscience. 2026. doi:10.1038/s41593-026-02237-9

Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy.

Moon JS, Moutusy SI, Zhang M, et al. Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy. Proceedings of the National Academy of Sciences of the United States of America. 2026;123(14):e2537271123. doi:10.1073/pnas.2537271123

Search for a genetic cause of variably protease-sensitive prionopathy.

Lian Y, Kotobelli K, Hall S, et al. Search for a genetic cause of variably protease-sensitive prionopathy. PLoS pathogens. 2025;21(8):e1013343. doi:10.1371/journal.ppat.1013343

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus.

Mandell KAP, Simmons SK, Nadig A, et al. Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus. Translational psychiatry. 2025;15(1):345. doi:10.1038/s41398-025-03563-5

Cassini: streamlined and scalable method for in situ profiling of RNA and protein.

Lapique N, Kim MT, Thom N, Nadaf NM, Pineda J, Macosko EZ. Cassini: streamlined and scalable method for in situ profiling of RNA and protein. Nature communications. 2025;16(1):8747. doi:10.1038/s41467-025-63798-0

Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues using STARmap PLUS, RIBOmap and TEMPOmap.

Ren J, Zeng H, Huang J, et al. Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues using STARmap PLUS, RIBOmap and TEMPOmap. Nature protocols. 2025. doi:10.1038/s41596-025-01248-3

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder.

Song BJ, Ge Y, Nicolella A, et al. Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder. Nature communications. 2025;16(1):10793. doi:10.1038/s41467-025-66504-2

Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda.

Stevenson A, Akena D, Stroud RE, et al. Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda. BMJ Open. 2019;9(2):e025469. doi:10.1136/bmjopen-2018-025469