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Brain Health

Srrm2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a genetic mouse model of schizophrenia.

Aryal S, Geng C, Yin MA, et al. Srrm2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a genetic mouse model of schizophrenia. Cell reports. 2026;45(6):117436. doi:10.1016/j.celrep.2026.117436

Multimodal analysis reveals cellular diversity and divergent circuits of the zona incerta.

Kast R, Simmons SK, Rome N, et al. Multimodal analysis reveals cellular diversity and divergent circuits of the zona incerta. Proceedings of the National Academy of Sciences of the United States of America. 2026;123(18):e2509781123. doi:10.1073/pnas.2509781123

Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy.

Moon JS, Moutusy SI, Zhang M, et al. Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy. Proceedings of the National Academy of Sciences of the United States of America. 2026;123(14):e2537271123. doi:10.1073/pnas.2537271123

Experimental and computational methods for allelic imbalance analysis from single-nucleus RNA-seq data.

Simmons SK, Adiconis X, Haywood N, et al. Experimental and computational methods for allelic imbalance analysis from single-nucleus RNA-seq data. Genome biology. 2026. doi:10.1186/s13059-026-04062-6

Putting polygenic scores in context: How intersectional factors affect relative and absolute genetic risk.

Cudic M, Tubbs JD, Ge T, Smoller JW. Putting polygenic scores in context: How intersectional factors affect relative and absolute genetic risk. American journal of human genetics. 2026. doi:10.1016/j.ajhg.2026.03.013

Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na channel dynamics in human neurons.

Cui L, Kurganov E, Hawes D, et al. Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na channel dynamics in human neurons. Molecular psychiatry. 2026. doi:10.1038/s41380-026-03587-3

Divalent siRNA for prion disease.

Gentile JE, Corridon TL, Serack FE, et al. Divalent siRNA for prion disease. Nucleic acids research. 2026;54(8). doi:10.1093/nar/gkag287

Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia.

Zhou T, Ho YY, Hartley ND, et al. Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia. Nature neuroscience. 2026. doi:10.1038/s41593-026-02237-9

Blocking RAN translation without altering repeat RNAs rescues -related ALS and FTD phenotypes.

Jiang X, Schaeffer L, Patni D, et al. Blocking RAN translation without altering repeat RNAs rescues -related ALS and FTD phenotypes. Science (New York, N.Y.). 2026;391(6785):eadv2600. doi:10.1126/science.adv2600

Pyramidal neurons proportionately alter cortical interneuron subtypes.

Wu SJ, Dai M, Yang SP, et al. Pyramidal neurons proportionately alter cortical interneuron subtypes. Nature. 2026. doi:10.1038/s41586-025-09996-8