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Cardiovascular disease

The Inherited Basis of Coronary Artery Disease

Schunkert H, Natarajan P, Samani NJ. The Inherited Basis of Coronary Artery Disease. New England Journal of Medicine. 2026;(394). doi:10.1056/NEJMra2405153

The OurHealth Study: A digital genomic cohort for cardiometabolic risk mechanisms in US South Asians.

Ganesh S, Bhattacharya R, Bhatnagar A, et al. The OurHealth Study: A digital genomic cohort for cardiometabolic risk mechanisms in US South Asians. NPJ digital medicine. 2026. doi:10.1038/s41746-025-02335-1

Loss of Mtarc1 Protects Against Steatotic Liver Disease in Mice.

Yin X, Bickerton C, MacDonald B, et al. Loss of Mtarc1 Protects Against Steatotic Liver Disease in Mice. Liver international : official journal of the International Association for the Study of the Liver. 2026;46(2):e70507. doi:10.1111/liv.70507

Physical Activity and Cardiovascular Outcomes in Phenotype-Negative Cardiomyopathy Variant Carriers.

Ajufo E, Kany S, Jurgens SJ, et al. Physical Activity and Cardiovascular Outcomes in Phenotype-Negative Cardiomyopathy Variant Carriers. JAMA cardiology. 2025. doi:10.1001/jamacardio.2025.4466

An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy.

Huffman JE, Gaziano L, Sayed ZRA, et al. An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy. Nature genetics. 2025. doi:10.1038/s41588-025-02372-2

Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation.

Zhang R, Kim MS, Yin W, et al. Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation. JAMA cardiology. 2025. doi:10.1001/jamacardio.2025.3664

A Deep Learning Model to Identify Mitral Valve Prolapse From the Echocardiogram.

Al-Alusi MA, Lau ES, Small AM, et al. A Deep Learning Model to Identify Mitral Valve Prolapse From the Echocardiogram. JACC. Cardiovascular imaging. 2025. doi:10.1016/j.jcmg.2025.08.011

Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies.

Maamari DJ, Biddinger KJ, Jurgens SJ, et al. Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. JAMA cardiology. 2025. doi:10.1001/jamacardio.2025.3248

Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation: Results in 18,000 Clinical Trial Participants.

Jurgens SJ, Melloni GEM, Kany S, et al. Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation: Results in 18,000 Clinical Trial Participants. Journal of the American College of Cardiology. 2025;86(10):738-753. doi:10.1016/j.jacc.2025.06.052

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.

Small AM, Yang TY, Itoh S, et al. Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction. Nature genetics. 2025. doi:10.1038/s41588-025-02417-6