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Infectious Disease and Microbiome Program, Infectious Disease and Microbiome

Digital CRISPR-based diagnostics for quantification of Candida auris and resistance mutations.

Rolando JC, Thieme A, Weckman NE, et al. Digital CRISPR-based diagnostics for quantification of Candida auris and resistance mutations. Nature biomedical engineering. 2026. doi:10.1038/s41551-025-01597-0

Intelectin-2 is a broad-spectrum antimicrobial lectin.

Dugan AE, Syangtan D, Nonnecke EB, et al. Intelectin-2 is a broad-spectrum antimicrobial lectin. Nature communications. 2026;17(1):231. doi:10.1038/s41467-025-67099-4

Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism.

Goering ER, Clatworthy AE, Parada-Kusz M, Bagnall J, Hung DT. Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism. PLoS pathogens. 2025;21(10):e1013273. doi:10.1371/journal.ppat.1013273

Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly.

Yu Z, Sathyanarayana P, Liu C, et al. Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly. Cell. 2025. doi:10.1016/j.cell.2025.11.041

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis.

Bond AN, Orzechowski M, Zhang S, et al. Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis. Nature communications. 2025;16(1):9673. doi:10.1038/s41467-025-64662-x

Predicting functions of uncharacterized gene products from microbial communities.

Zhang Y, Bhosle A, Bae S, et al. Predicting functions of uncharacterized gene products from microbial communities. Nature biotechnology. 2025. doi:10.1038/s41587-025-02813-7

The carbapenem inoculum effect provides insights into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales.

Cartagena AJ, Taylor KL, Lopez LC, et al. The carbapenem inoculum effect provides insights into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales. mBio. 2025:e0154025. doi:10.1128/mbio.01540-25

Insights Into Global Antimicrobial Resistance Dynamics Through the Sequencing of Enteric Bacteria From US International Travelers.

Sridhar S, Worby CJ, Bronson RA, et al. Insights Into Global Antimicrobial Resistance Dynamics Through the Sequencing of Enteric Bacteria From US International Travelers. The Journal of infectious diseases. 2025. doi:10.1093/infdis/jiaf469

Bead-based approaches for increased sensitivity and multiplexing of CRISPR diagnostics.

Siddiqui SM, Welch NL, Nguyen TG, et al. Bead-based approaches for increased sensitivity and multiplexing of CRISPR diagnostics. Nature biomedical engineering. 2025. doi:10.1038/s41551-025-01498-2

Circulating tumor human papillomavirus DNA whole genome sequencing enables human papillomavirus-associated oropharynx cancer early detection.

Das D, Hirayama S, Aye L, et al. Circulating tumor human papillomavirus DNA whole genome sequencing enables human papillomavirus-associated oropharynx cancer early detection. Journal of the National Cancer Institute. 2025. doi:10.1093/jnci/djaf249