Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Alzheimers Dement

Authors	Gyungah Jun Jaeyoon Chung Jesse Mez Robert Barber Gary Beecham David Bennett Joseph Buxbaum Goldie Byrd Minerva Carrasquillo Paul Crane Carlos Cruchaga Philip De Jager Nilüfer Ertekin-Taner Denis Evans M Danielle Fallin Tatiana Foroud Robert Friedland Alison Goate Neill Graff-Radford Hugh Hendrie Kathleen Hall Kara Hamilton-Nelson Rivka Inzelberg M Ilyas Kamboh John Kauwe Walter Kukull Brian Kunkle Ryozo Kuwano Eric Larson Mark Logue Jennifer Manly Eden Martin Thomas Montine Shubhabrata Mukherjee Adam Naj Eric Reiman Christiane Reitz Richard Sherva Peter St George-Hyslop Timothy Thornton Steven Younkin Badri Vardarajan Li- San Wang Jens Wendlund Ashley Winslow Alzheimer's Disease Genetics Consortium Jonathan Haines Richard Mayeux Margaret Pericak-Vance Gerard Schellenberg Kathryn Lunetta Lindsay Farrer
Abstract	INTRODUCTION: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. METHODS: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. RESULTS: Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 × 10(-8)) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ɛ4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 × 10(-6)) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10(-6)). DISCUSSION: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.
Year of Publication	2017
Journal	Alzheimers Dement
Date Published	2017 Feb 07
ISSN	1552-5279
DOI	10.1016/j.jalz.2016.12.012
PubMed ID	28183528
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Grant list	R01 AG054060 / AG / NIA NIH HHS / United States U24 AG021886 / AG / NIA NIH HHS / United States U01 AG032984 / AG / NIA NIH HHS / United States U01 AG016976 / AG / NIA NIH HHS / United States P30 AG010161 / AG / NIA NIH HHS / United States R01 AG048927 / AG / NIA NIH HHS / United States R01 AG025259 / AG / NIA NIH HHS / United States