Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction.
Org Lett
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| Abstract | A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted gamma-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct. |
| Year of Publication | 2007
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| Journal | Org Lett
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| Volume | 9
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| Issue | 20
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| Pages | 4077-80
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| Date Published | 2007 Sep 27
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| ISSN | 1523-7060
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| URL | |
| DOI | 10.1021/ol701911u
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| PubMed ID | 17760458
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| Grant list | P50 GM069721 / GM / NIGMS NIH HHS / United States
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