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An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries.

Mulrooney CA, Lahr DL, Quintin MJ, et al. An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries. J Comput Aided Mol Des. 2013;27(5):455-68. doi:10.1007/s10822-013-9641-y

A small-molecule inducer of PDX1 expression identified by high-throughput screening.

Yuan Y, Hartland K, Boskovic Z, et al. A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem Biol. 2013;20(12):1513-22. doi:10.1016/j.chembiol.2013.10.013

High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development.

Sharma K, Choi SY, Zhang Y, et al. High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development. Cell Rep. 2013;5(5):1330-41. doi:10.1016/j.celrep.2013.11.008

Bacterial toxins and small molecules elucidate endosomal trafficking.

Slater LH, Clatworthy AE, Hung DT. Bacterial toxins and small molecules elucidate endosomal trafficking. Trends Microbiol. 2014;22(2):53-5. doi:10.1016/j.tim.2013.12.002

Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.

Dančík V, Carrel H, Bodycombe NE, et al. Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses. J Biomol Screen. 2014;19(5):771-81. doi:10.1177/1087057113520226

Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth.

Stanley SA, Barczak AK, Silvis MR, et al. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 2014;10(2):e1003946. doi:10.1371/journal.ppat.1003946

Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons.

Fischer K, Kettunen J, Würtz P, et al. Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons. PLoS Med. 2014;11(2):e1001606. doi:10.1371/journal.pmed.1001606

High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons.

Nieland TJF, Logan DJ, Saulnier J, et al. High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons. PLoS One. 2014;9(3):e91744. doi:10.1371/journal.pone.0091744

Identification of small molecules for human hepatocyte expansion and iPS differentiation.

Shan J, Schwartz RE, Ross NT, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013;9(8):514-20. doi:10.1038/nchembio.1270

Increasing the Content of High-Content Screening: An Overview.

Singh S, Carpenter AE, Genovesio A. Increasing the Content of High-Content Screening: An Overview. J Biomol Screen. 2014;19(5):640-50. doi:10.1177/1087057114528537