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Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.

Bonàs-Guarch S, Guindo-Martínez M, Miguel-Escalada I, et al. Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. Nat Commun. 2018;9(1):321. doi:10.1038/s41467-017-02380-9

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.

Wardell CP, Fujita M, Yamada T, et al. Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. J Hepatol. 2018;68(5):959-969. doi:10.1016/j.jhep.2018.01.009

KANSL1 variation is not a major contributing factor in self-limited focal epilepsy syndromes of childhood.

Myers KA, McGlade A, Neubauer BA, et al. KANSL1 variation is not a major contributing factor in self-limited focal epilepsy syndromes of childhood. PLoS One. 2018;13(1):e0191546. doi:10.1371/journal.pone.0191546

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Jiang X, O’Reilly PF, Aschard H, et al. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nat Commun. 2018;9(1):260. doi:10.1038/s41467-017-02662-2

Spatiotemporal allele organization by allele-specific CRISPR live-cell imaging (SNP-CLING).

Maass PG, Barutcu R, Shechner DM, Weiner CL, Melé M, Rinn JL. Spatiotemporal allele organization by allele-specific CRISPR live-cell imaging (SNP-CLING). Nat Struct Mol Biol. 2018;25(2):176-184. doi:10.1038/s41594-017-0015-3

Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations.

Gazal S, Loh PR, Finucane HK, et al. Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations. Nat Genet. 2018;50(11):1600-1607. doi:10.1038/s41588-018-0231-8

The critical needs and challenges for genetic architecture studies in Africa.

Martin AR, Teferra S, Möller M, Hoal EG, Daly MJ. The critical needs and challenges for genetic architecture studies in Africa. Curr Opin Genet Dev. 2018;53:113-120. doi:10.1016/j.gde.2018.08.005

Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).

Lam M, Trampush JW, Yu J, et al. Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018). Twin Res Hum Genet. 2018;21(5):394-397. doi:10.1017/thg.2018.46

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits.

Hormozdiari F, Gazal S, van de Geijn B, et al. Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. Nat Genet. 2018;50(7):1041-1047. doi:10.1038/s41588-018-0148-2

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.

Ni G, Moser G, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Wray NR, Lee H. Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood. Am J Hum Genet. 2018;102(6):1185-1194. doi:10.1016/j.ajhg.2018.03.021