ӳ��ý

Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants.

Iqbal S, Pérez-Palma E, Jespersen JB, et al. Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants. Proc Natl Acad Sci U S A. 2020;117(45):28201-28211. doi:10.1073/pnas.2002660117

Acquired Resistance to KRAS Inhibition in Cancer.

Awad MM, Liu S, Rybkin II, et al. Acquired Resistance to KRAS Inhibition in Cancer. N Engl J Med. 2021;384(25):2382-2393. doi:10.1056/NEJMoa2105281

Critical assessment of protein intrinsic disorder prediction.

Necci M, Piovesan D, CAID Predictors, DisProt Curators, Tosatto SCE. Critical assessment of protein intrinsic disorder prediction. Nat Methods. 2021;18(5):472-481. doi:10.1038/s41592-021-01117-3

Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein.

Rosen MK, Michnick SW, Karplus M, Schreiber SL. Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein. Biochemistry. 1991;30(19):4774-89.

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation.

Zhang Z, Boskovic Z, Hussain MM, et al. Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation. Elife. 2015;4. doi:10.7554/eLife.07777

Regulatory intramolecular association in a tyrosine kinase of the Tec family.

Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL. Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature. 1997;385(6611):93-7. doi:10.1038/385093a0

Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis.

Feng S, Kapoor TM, Shirai F, Combs AP, Schreiber SL. Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chem Biol. 1996;3(8):661-70.

Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins.

Belshaw PJ, Ho SN, Crabtree GR, Schreiber SL. Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proc Natl Acad Sci U S A. 1996;93(10):4604-7.

Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands.

Feng S, Kasahara C, Rickles RJ, Schreiber SL. Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands. Proc Natl Acad Sci U S A. 1995;92(26):12408-15.

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

Chen J, Zheng XF, Brown EJ, Schreiber SL. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci U S A. 1995;92(11):4947-51.