Rees MG, Seashore-Ludlow B, Cheah JH, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nat Chem Biol. 2016;12(2):109-16. doi:10.1038/nchembio.1986
Sykes DB, Kfoury YS, Mercier FE, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016;167(1):171-186.e15. doi:10.1016/j.cell.2016.08.057
Davis KM, Pattanayak V, Thompson DB, Zuris JA, Liu DR. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015;11(5):316-8. doi:10.1038/nchembio.1793
McGregor LM, Jain T, Liu DR. Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates. J Am Chem Soc. 2014;136(8):3264-70. doi:10.1021/ja412934t
Wagner BK, Schreiber SL. The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods. Cell Chem Biol. 2016;23(1):3-9. doi:10.1016/j.chembiol.2015.11.008
Johannessen CM, Clemons PA, Wagner BK. Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery. Trends Genet. 2015;31(1):16-23. doi:10.1016/j.tig.2014.11.002
Lundh M, Scully SS, Mandrup-Poulsen T, Wagner BK. Small-molecule inhibition of inflammatory β-cell death. Diabetes Obes Metab. 2013;15 Suppl 3:176-84. doi:10.1111/dom.12158
Schenone M, Dančík V, Wagner BK, Clemons PA. Target identification and mechanism of action in chemical biology and drug discovery. Nat Chem Biol. 2013;9(4):232-40. doi:10.1038/nchembio.1199
Wagner BK. Grand challenge commentary: Chemical transdifferentiation and regenerative medicine. Nat Chem Biol. 2010;6(12):877-9. doi:10.1038/nchembio.472
Chou DHC, Bodycombe NE, Carrinski HA, et al. Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis. ACS Chem Biol. 2010;5(8):729-34. doi:10.1021/cb100129d