Chordoma is literally a one in a million cancer, with few effective treatment options. A new understanding of the biology behind this tumor type is bringing novel opportunities to light.
Using a new model dubbed DEMETER2, the Ó³»´«Ã½'s Cancer Dependency Map team has compiled the largest dataset of genetic dependencies in cancer to date.
Laboratory study suggests that thalidomide-like drugs could be designed to target a broad array of transcription factors, and open a new landscape of cancer drug development.
Researchers identify a molecular strategy that human melanoma cells use to resist immunotherapy, and develop a new approach to combat the resistance in mouse models