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Small-molecule-sensitivity profiling of cancer cell lines (CCLs) has emerged as an approach to illuminate the mechanism of action of compounds and to launch the early stage of the discovery of new precision therapies. In a study in , a team of scientists from ӳý's  — led by researchers Stuart Schreiber, Paul Clemons, and Alykhan Shamji — presents the largest CCL sensitivity dataset to date, and an exciting new analysis method, termed “annotated cluster multi-dimensional enrichment” (ACME), integrating information from multiple CCLs and small molecules.

The gene CARD9 codes for a central component of the innate anti-fungal immune response and has recently been associated with risk for several immune-related disorders, including inflammatory bowel disease (IBD). New research from the lab of ӳý institute member looks to a rare CARD9 variant, which is strongly protective against IBD, to uncover the basic biology of the gene as well as its regulation. , published this week in Immunity, also offers a potential mechanism for the protective allele.

An international team of CRISPR-Cas researchers has identified three new naturally-occurring systems that show potential for genome editing. The discovery and characterization of these systems is expected to further expand the genome editing toolbox, opening new avenues for biomedical research. The research, published today in the journal , was supported in part by the National Institutes of Health.