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Immunology Program

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.

Barilla RM, Berard C, Sun L, et al. Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense. Science (New York, N.Y.). 2025;389(6757):260-267. doi:10.1126/science.adn9850

Neuroimmune Circuits in Allergic Diseases.

Han C, Zhu X, Sokol CL. Neuroimmune Circuits in Allergic Diseases. Annual review of immunology. 2025;43(1):367-394. doi:10.1146/annurev-immunol-082423-032154

Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution.

Watson BR, Paul B, Rahman RU, et al. Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution. Nature communications. 2025;16(1):319. doi:10.1038/s41467-024-55325-4

B cell tolerance and autoimmunity: Lessons from repertoires.

Deguine J, Xavier RJ. B cell tolerance and autoimmunity: Lessons from repertoires. The Journal of experimental medicine. 2024;221(9). doi:10.1084/jem.20231314

Spatially restricted immune and microbiota-driven adaptation of the gut.

Mayassi T, Li C, Segerstolpe Å, et al. Spatially restricted immune and microbiota-driven adaptation of the gut. Nature. 2024. doi:10.1038/s41586-024-08216-z

A γδ T cell-IL-3 axis controls allergic responses through sensory neurons.

Flayer CH, Kernin IJ, Matatia PR, et al. A γδ T cell-IL-3 axis controls allergic responses through sensory neurons. Nature. 2024;634(8033):440-446. doi:10.1038/s41586-024-07869-0

Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation.

Neale I, Reddy C, Tan ZY, et al. Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation. Science advances. 2024;10(29):eadn2339. doi:10.1126/sciadv.adn2339

Immune responses in checkpoint myocarditis across heart, blood and tumour.

Blum SM, Zlotoff DA, Smith NP, et al. Immune responses in checkpoint myocarditis across heart, blood and tumour. Nature. 2024. doi:10.1038/s41586-024-08105-5

Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis.

Thomas MF, Slowikowski K, Manakongtreecheep K, et al. Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis. Nature medicine. 2024. doi:10.1038/s41591-024-02895-x

Neuropeptide signalling orchestrates T cell differentiation.

Hou Y, Sun L, LaFleur MW, et al. Neuropeptide signalling orchestrates T cell differentiation. Nature. 2024. doi:10.1038/s41586-024-08049-w