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Immunology Program

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.

Barilla RM, Berard C, Sun L, et al. Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense. Science (New York, N.Y.). 2025;389(6757):260-267. doi:10.1126/science.adn9850

Neuroimmune Circuits in Allergic Diseases.

Han C, Zhu X, Sokol CL. Neuroimmune Circuits in Allergic Diseases. Annual review of immunology. 2025;43(1):367-394. doi:10.1146/annurev-immunol-082423-032154

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation.

Xu J, Kong L, Creasey EA, et al. Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation. The Journal of experimental medicine. 2025;222(11). doi:10.1084/jem.20250185

Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation.

Chen X, Hwang H, Li B, et al. Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(38):e2508269122. doi:10.1073/pnas.2508269122

Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution.

Watson BR, Paul B, Rahman RU, et al. Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution. Nature communications. 2025;16(1):319. doi:10.1038/s41467-024-55325-4

Elucidating the role of Campylobacter concisus-derived indole metabolites in gut inflammation and immune modulation.

Park JD, Lee SR, Dhennezel C, et al. Elucidating the role of Campylobacter concisus-derived indole metabolites in gut inflammation and immune modulation. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(34):e2514071122. doi:10.1073/pnas.2514071122

B cell tolerance and autoimmunity: Lessons from repertoires.

Deguine J, Xavier RJ. B cell tolerance and autoimmunity: Lessons from repertoires. The Journal of experimental medicine. 2024;221(9). doi:10.1084/jem.20231314

Spatially restricted immune and microbiota-driven adaptation of the gut.

Mayassi T, Li C, Segerstolpe Å, et al. Spatially restricted immune and microbiota-driven adaptation of the gut. Nature. 2024. doi:10.1038/s41586-024-08216-z

A γδ T cell-IL-3 axis controls allergic responses through sensory neurons.

Flayer CH, Kernin IJ, Matatia PR, et al. A γδ T cell-IL-3 axis controls allergic responses through sensory neurons. Nature. 2024;634(8033):440-446. doi:10.1038/s41586-024-07869-0

Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation.

Neale I, Reddy C, Tan ZY, et al. Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation. Science advances. 2024;10(29):eadn2339. doi:10.1126/sciadv.adn2339