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Immunology Program

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation.

Tan P, Jaiswal A, Murphy SP, et al. Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation. Science (New York, N.Y.). 2025;390(6772):eadr3545. doi:10.1126/science.adr3545

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation.

Xu J, Kong L, Creasey EA, et al. Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation. The Journal of experimental medicine. 2025;222(11). doi:10.1084/jem.20250185

Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation.

Chen X, Hwang H, Li B, et al. Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(38):e2508269122. doi:10.1073/pnas.2508269122

Elucidating the role of Campylobacter concisus-derived indole metabolites in gut inflammation and immune modulation.

Park JD, Lee SR, Dhennezel C, et al. Elucidating the role of Campylobacter concisus-derived indole metabolites in gut inflammation and immune modulation. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(34):e2514071122. doi:10.1073/pnas.2514071122

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.

Barilla RM, Berard C, Sun L, et al. Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense. Science (New York, N.Y.). 2025;389(6757):260-267. doi:10.1126/science.adn9850

Neuroimmune Circuits in Allergic Diseases.

Han C, Zhu X, Sokol CL. Neuroimmune Circuits in Allergic Diseases. Annual review of immunology. 2025;43(1):367-394. doi:10.1146/annurev-immunol-082423-032154

Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution.

Watson BR, Paul B, Rahman RU, et al. Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution. Nature communications. 2025;16(1):319. doi:10.1038/s41467-024-55325-4

Immune responses in checkpoint myocarditis across heart, blood and tumour.

Blum SM, Zlotoff DA, Smith NP, et al. Immune responses in checkpoint myocarditis across heart, blood and tumour. Nature. 2024. doi:10.1038/s41586-024-08105-5

A γδ T cell-IL-3 axis controls allergic responses through sensory neurons.

Flayer CH, Kernin IJ, Matatia PR, et al. A γδ T cell-IL-3 axis controls allergic responses through sensory neurons. Nature. 2024;634(8033):440-446. doi:10.1038/s41586-024-07869-0

Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator.

Tan ZY, Adade JKA, Gu X, et al. Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator. Cell chemical biology. 2024. doi:10.1016/j.chembiol.2024.12.002