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Immunology Program

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.

Rush JS, Wertheimer JD, Goldberg SD, et al. Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity. Cell. 2026. doi:10.1016/j.cell.2025.12.013

Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution.

Watson BR, Paul B, Rahman RU, et al. Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution. Nature communications. 2025;16(1):319. doi:10.1038/s41467-024-55325-4

Neuroimmune Circuits in Allergic Diseases.

Han C, Zhu X, Sokol CL. Neuroimmune Circuits in Allergic Diseases. Annual review of immunology. 2025;43(1):367-394. doi:10.1146/annurev-immunol-082423-032154

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.

Barilla RM, Berard C, Sun L, et al. Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense. Science (New York, N.Y.). 2025;389(6757):260-267. doi:10.1126/science.adn9850

Elucidating the role of Campylobacter concisus-derived indole metabolites in gut inflammation and immune modulation.

Park JD, Lee SR, Dhennezel C, et al. Elucidating the role of Campylobacter concisus-derived indole metabolites in gut inflammation and immune modulation. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(34):e2514071122. doi:10.1073/pnas.2514071122

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation.

Xu J, Kong L, Creasey EA, et al. Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation. The Journal of experimental medicine. 2025;222(11). doi:10.1084/jem.20250185

Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy.

Giovannoni F, Strathdee CA, Akl CF, et al. Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy. Nature cancer. 2025. doi:10.1038/s43018-025-01070-6

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation.

Tan P, Jaiswal A, Murphy SP, et al. Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation. Science (New York, N.Y.). 2025;390(6772):eadr3545. doi:10.1126/science.adr3545

Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation.

Chen X, Hwang H, Li B, et al. Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(38):e2508269122. doi:10.1073/pnas.2508269122

Spatially restricted immune and microbiota-driven adaptation of the gut.

Mayassi T, Li C, Segerstolpe Å, et al. Spatially restricted immune and microbiota-driven adaptation of the gut. Nature. 2024. doi:10.1038/s41586-024-08216-z