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Immunology Program

A γδ T cell-IL-3 axis controls allergic responses through sensory neurons.

Flayer CH, Kernin IJ, Matatia PR, et al. A γδ T cell-IL-3 axis controls allergic responses through sensory neurons. Nature. 2024;634(8033):440-446. doi:10.1038/s41586-024-07869-0

Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator.

Tan ZY, Adade JKA, Gu X, et al. Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator. Cell chemical biology. 2024. doi:10.1016/j.chembiol.2024.12.002

Immune responses in checkpoint myocarditis across heart, blood and tumour.

Blum SM, Zlotoff DA, Smith NP, et al. Immune responses in checkpoint myocarditis across heart, blood and tumour. Nature. 2024. doi:10.1038/s41586-024-08105-5

Neuropeptide signalling orchestrates T cell differentiation.

Hou Y, Sun L, LaFleur MW, et al. Neuropeptide signalling orchestrates T cell differentiation. Nature. 2024. doi:10.1038/s41586-024-08049-w

Identifying genetic variants that influence the abundance of cell states in single-cell data.

Rumker L, Sakaue S, Reshef Y, et al. Identifying genetic variants that influence the abundance of cell states in single-cell data. Nature genetics. 2024. doi:10.1038/s41588-024-01909-1

Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis.

Brown EM, Nguyen PNU, Xavier RJ. Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis. Cell chemical biology. 2024. doi:10.1016/j.chembiol.2024.07.012

B cell tolerance and autoimmunity: Lessons from repertoires.

Deguine J, Xavier RJ. B cell tolerance and autoimmunity: Lessons from repertoires. The Journal of experimental medicine. 2024;221(9). doi:10.1084/jem.20231314

Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation.

Neale I, Reddy C, Tan ZY, et al. Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation. Science advances. 2024;10(29):eadn2339. doi:10.1126/sciadv.adn2339

Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis.

Thomas MF, Slowikowski K, Manakongtreecheep K, et al. Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis. Nature medicine. 2024. doi:10.1038/s41591-024-02895-x

Airway hillocks are injury-resistant reservoirs of unique plastic stem cells.

Lin B, Shah VS, Chernoff C, et al. Airway hillocks are injury-resistant reservoirs of unique plastic stem cells. Nature. 2024. doi:10.1038/s41586-024-07377-1