Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders. Zhou Z, Luquette LJ, Dong G, et al. Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders. Cell. 2026. doi:10.1016/j.cell.2026.06.013 PMCID PMC13340254 Read more
NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease. Nazeen S, Wang X, Morrow AR, et al. NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson’s disease. Cell genomics. 2026:101284. doi:10.1016/j.xgen.2026.101284 Read more
DiscoDivas: Leveraging genetic-ancestry continuum information to interpolate PRS for admixed populations. Ruan Y, Bhukar R, Patel A, et al. DiscoDivas: Leveraging genetic-ancestry continuum information to interpolate PRS for admixed populations. American journal of human genetics. 2026. doi:10.1016/j.ajhg.2026.05.006 Read more
A multi-ethnic reference map of T cell receptor germline diversity reveals evidence of natural selection on alpha chain genes. Mantena S, Edahiro R, Okada Y, Akbari A, Raychaudhuri S. A multi-ethnic reference map of T cell receptor germline diversity reveals evidence of natural selection on alpha chain genes. Nature communications. 2026. doi:10.1038/s41467-026-73730-9 Read more
Automated reanalysis of genomic data for rare disease diagnostics at scale. Welland MJ, Ahlquist KD, De Fazio P, et al. Automated reanalysis of genomic data for rare disease diagnostics at scale. Nature medicine. 2026. doi:10.1038/s41591-026-04477-5 Read more
Transcriptome predictors of second breast events in ductal carcinoma in situ: a case‒control study including Black and White women. Hazra A, Berdan E, Walsh T, et al. Transcriptome predictors of second breast events in ductal carcinoma in situ: a case‒control study including Black and White women. Breast cancer research : BCR. 2026;28(1). doi:10.1186/s13058-026-02257-0 PMCID PMC13169648 Read more
Modular genetic architecture underlies human hand and foot evolution. Okamoto AS, Senevirathne G, Muthuirulan P, et al. Modular genetic architecture underlies human hand and foot evolution. Proceedings of the National Academy of Sciences of the United States of America. 2026;123(20):e2603297123. doi:10.1073/pnas.2603297123 Read more
Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells. Lyu P, Agarwal G, Guo CJ, et al. Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells. Cell. 2026. doi:10.1016/j.cell.2026.04.014 Read more
Genetic variants affect diurnal glucose levels throughout the day. Sinnott-Armstrong N, Strausz S, Urpa L, et al. Genetic variants affect diurnal glucose levels throughout the day. Nature communications. 2026. doi:10.1038/s41467-026-72432-6 Read more
Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations. Koyama S, Yu Z, Choi SH, et al. Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations. Nature genetics. 2026. doi:10.1038/s41588-026-02613-y Read more