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Stanley Center for Psychiatric Research

ChAT-ChR2-EYFP mice have enhanced motor endurance but show deficits in attention and several additional cognitive domains.

Kolisnyk B, Guzman MS, Raulic S, et al. ChAT-ChR2-EYFP mice have enhanced motor endurance but show deficits in attention and several additional cognitive domains. J Neurosci. 2013;33(25):10427-38. doi:10.1523/JNEUROSCI.0395-13.2013

Discovery of the first histone deacetylase 6/8 dual inhibitors.

Olson DE, Wagner FF, Kaya T, et al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013;56(11):4816-20. doi:10.1021/jm400390r

Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.

Ferguson BS, Harrison BC, Jeong MY, et al. Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2013;110(24):9806-11. doi:10.1073/pnas.1301509110

Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors.

Burguière E, Monteiro P, Feng G, Graybiel AM. Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science. 2013;340(6137):1243-6. doi:10.1126/science.1232380

Optical inhibition of motor nerve and muscle activity in vivo.

Liske H, Towne C, Anikeeva P, et al. Optical inhibition of motor nerve and muscle activity in vivo. Muscle Nerve. 2013;47(6):916-21. doi:10.1002/mus.23696

Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation.

Frumm SM, Fan ZP, Ross KN, et al. Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation. Chem Biol. 2013;20(5):713-25. doi:10.1016/j.chembiol.2013.03.020

Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.

Wagner FF, Olson DE, Gale JP, et al. Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem. 2013;56(4):1772-6. doi:10.1021/jm301355j

Cortical control of affective networks.

Kumar S, Black SJ, Hultman R, et al. Cortical control of affective networks. J Neurosci. 2013;33(3):1116-29. doi:10.1523/JNEUROSCI.0092-12.2013

Next-generation transgenic mice for optogenetic analysis of neural circuits.

Asrican B, Augustine GJ, Berglund K, et al. Next-generation transgenic mice for optogenetic analysis of neural circuits. Front Neural Circuits. 2013;7:160. doi:10.3389/fncir.2013.00160

Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.

Wang C, Eessalu TE, Barth VN, et al. Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. Am J Nucl Med Mol Imaging. 2013;4(1):29-38.