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Cancer Program

A context-augmented large language model for accurate precision oncology medicine recommendations.

Jun H, Tanaka Y, Johri S, et al. A context-augmented large language model for accurate precision oncology medicine recommendations. Cancer cell. 2026. doi:10.1016/j.ccell.2025.12.017

Deep learning guided design of protease substrates.

Martin-Alonso C, Alamdari S, Samad TS, Yang KK, Bhatia SN, Amini AP. Deep learning guided design of protease substrates. Nature communications. 2026;17(1):54. doi:10.1038/s41467-025-67226-1

Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity.

Pimenta EM, Garza AE, Camp SY, et al. Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity. Science translational medicine. 2026;18(833):eadw4689. doi:10.1126/scitranslmed.adw4689

Nutrient requirements of organ-specific metastasis in breast cancer.

Abbott KL, Subudhi S, Ferreira R, et al. Nutrient requirements of organ-specific metastasis in breast cancer. Nature. 2026. doi:10.1038/s41586-025-09898-9

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma.

Pilcher WC, Yao L, Gonzalez-Kozlova E, et al. A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma. Nature cancer. 2026. doi:10.1038/s43018-025-01072-4

Genomic landscape and immunological profile of glioblastoma in East Asian patients.

Zhong S, Wu B, Dubois F, et al. Genomic landscape and immunological profile of glioblastoma in East Asian patients. Cell reports. Medicine. 2025;6(8):102217. doi:10.1016/j.xcrm.2025.102217

A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.

Apfelbaum AA, Morin E, Sturm D, et al. A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas. Nature communications. 2025;16(1):7018. doi:10.1038/s41467-025-61820-z

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma.

Knudsen NH, Escobar G, Korell F, et al. In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma. Nature. 2025. doi:10.1038/s41586-025-09489-8

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma.

Yang J, Wang C, Fu D, et al. Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma. Nature communications. 2025;16(1):8151. doi:10.1038/s41467-025-62878-5

Integrative genomic identification of therapeutic targets for pancreatic cancer.

Guo JA, Gong D, Evans K, et al. Integrative genomic identification of therapeutic targets for pancreatic cancer. Cell reports. 2025;44(9):116191. doi:10.1016/j.celrep.2025.116191