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Cancer Program

An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML.

Lin S, Larrue C, Scheidegger NK, et al. An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML. Cancer Discov. 2022;12(2):432-449. doi:10.1158/2159-8290.CD-20-1851

Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer.

Ouspenskaia T, Law T, Clauser KR, et al. Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer. Nat Biotechnol. 2022;40(2):209-217. doi:10.1038/s41587-021-01021-3

Somatic and germline genomic alterations in very young women with breast cancer.

Waks AG, Kim D, Jain E, et al. Somatic and germline genomic alterations in very young women with breast cancer. Clin Cancer Res. 2022. doi:10.1158/1078-0432.CCR-21-2572

Towards a Better Understanding of Antibody-Drug Conjugates in Urothelial Carcinoma.

Labaki C, Bakouny Z, Sonpavde G, Choueiri TK, Van Allen EM. Towards a Better Understanding of Antibody-Drug Conjugates in Urothelial Carcinoma. Eur Urol Oncol. 2022. doi:10.1016/j.euo.2022.01.004

Implementation of a prostate cancer-specific targeted sequencing panel for credentialing of patient-derived cell lines and genomic characterization of patient samples.

Stover EH, Oh C, Keskula P, et al. Implementation of a prostate cancer-specific targeted sequencing panel for credentialing of patient-derived cell lines and genomic characterization of patient samples. Prostate. 2022. doi:10.1002/pros.24305

Sparse dictionary learning recovers pleiotropy from human cell fitness screens.

Pan J, Kwon JJ, Talamas JA, et al. Sparse dictionary learning recovers pleiotropy from human cell fitness screens. Cell Syst. 2022. doi:10.1016/j.cels.2021.12.005

Massively parallel phenotyping of coding variants in cancer with Perturb-seq.

Ursu O, Neal JT, Shea E, et al. Massively parallel phenotyping of coding variants in cancer with Perturb-seq. Nat Biotechnol. 2022. doi:10.1038/s41587-021-01160-7

Single-cell profiling of tumour evolution in multiple myeloma - opportunities for precision medicine.

Dutta AK, Alberge JB, Sklavenitis-Pistofidis R, Lightbody ED, Getz G, Ghobrial IM. Single-cell profiling of tumour evolution in multiple myeloma - opportunities for precision medicine. Nat Rev Clin Oncol. 2022. doi:10.1038/s41571-021-00593-y

Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine.

Pages M, Rotem D, Gydush G, et al. Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine. Neuro Oncol. 2022. doi:10.1093/neuonc/noab299

Understanding CLL biology through mouse models of human genetics.

Hacken ET, Wu CJ. Understanding CLL biology through mouse models of human genetics. Blood. 2021;138(25):2621-2631. doi:10.1182/blood.2021011993