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Cancer Program

Targeting pan-essential genes in cancer: challenges and opportunities.

Chang L, Ruiz P, Ito T, Sellers WR. Targeting pan-essential genes in cancer: challenges and opportunities. Cancer Cell. 2021. doi:10.1016/j.ccell.2020.12.008

CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.

Belizaire R, Koochaki SHJ, Udeshi ND, et al. CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1. Blood. 2021. doi:10.1182/blood.2020006528

Natural Barcodes for Longitudinal Single Cell Tracking of Leukemic and Immune Cell Dynamics.

Penter L, Gohil SH, Wu CJ. Natural Barcodes for Longitudinal Single Cell Tracking of Leukemic and Immune Cell Dynamics. Front Immunol. 2021;12:788891. doi:10.3389/fimmu.2021.788891

Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer.

Malone CF, Dharia N V, Kugener G, et al. Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. Cancer discovery. 2021;11(9):2282-2299. doi:10.1158/2159-8290.CD-20-1213

Cancer research needs a better map.

Boehm JS, Garnett MJ, Adams DJ, et al. Cancer research needs a better map. Nature. 2021;589(7843):514-516. doi:10.1038/d41586-021-00182-0

Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.

Tothova Z, Valton AL, Gorelov R, et al. Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML. JCI Insight. 2020. doi:10.1172/jci.insight.142149

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.

Neggers JE, Paolella BR, Asfaw A, et al. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2020;33(11):108493. doi:10.1016/j.celrep.2020.108493

Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations.

Carrot-Zhang J, Soca-Chafre G, Patterson N, et al. Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations. Cancer Discov. 2020. doi:10.1158/2159-8290.CD-20-1165

A metastasis map of human cancer cell lines.

Jin X, Demere Z, Nair K, et al. A metastasis map of human cancer cell lines. Nature. 2020;588(7837):331-336. doi:10.1038/s41586-020-2969-2

Integrated molecular drivers coordinate biological and clinical states in melanoma.

Conway JR, Dietlein F, Taylor-Weiner A, et al. Integrated molecular drivers coordinate biological and clinical states in melanoma. Nat Genet. 2020;52(12):1373-1383. doi:10.1038/s41588-020-00739-1