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Publications

Maintenance of CD4 T cell fitness through regulation of Foxo1.

Newton RH, Shrestha S, Sullivan JM, et al. Maintenance of CD4 T cell fitness through regulation of Foxo1. Nat Immunol. 2018;19(8):838-848. doi:10.1038/s41590-018-0157-4

Genetic determinants of co-accessible chromatin regions in activated T cells across humans.

Gate RE, Cheng CS, Aiden AP, et al. Genetic determinants of co-accessible chromatin regions in activated T cells across humans. Nat Genet. 2018;50(8):1140-1150. doi:10.1038/s41588-018-0156-2

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.

Bunse L, Pusch S, Bunse T, et al. Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. Nat Med. 2018;24(8):1192-1203. doi:10.1038/s41591-018-0095-6

Molecular genetic overlap between migraine and major depressive disorder.

Yang Y, Zhao H, Boomsma DI, et al. Molecular genetic overlap between migraine and major depressive disorder. Eur J Hum Genet. 2018;26(8):1202-1216. doi:10.1038/s41431-018-0150-2

A synthetic-diploid benchmark for accurate variant-calling evaluation.

Li H, Bloom JM, Farjoun Y, et al. A synthetic-diploid benchmark for accurate variant-calling evaluation. Nat Methods. 2018;15(8):595-597. doi:10.1038/s41592-018-0054-7

An enhanced CRISPR repressor for targeted mammalian gene regulation.

Yeo NC, Chavez A, Lance-Byrne A, et al. An enhanced CRISPR repressor for targeted mammalian gene regulation. Nat Methods. 2018;15(8):611-616. doi:10.1038/s41592-018-0048-5

Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis.

Kowalec K, Wright GEB, Drögemöller BI, et al. Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis. Nat Genet. 2018;50(8):1081-1085. doi:10.1038/s41588-018-0168-y

High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction.

Li G, Martínez-Bonet M, Wu D, et al. High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction. Nat Genet. 2018;50(8):1180-1188. doi:10.1038/s41588-018-0159-z

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Waage J, Standl M, Curtin JA, et al. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018;50(8):1072-1080. doi:10.1038/s41588-018-0157-1

Accumulation of succinate controls activation of adipose tissue thermogenesis.

Mills EL, Pierce KA, Jedrychowski MP, et al. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018;560(7716):102-106. doi:10.1038/s41586-018-0353-2