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Publications

Precisely defining disease variant effects in CRISPR-edited single cells.

Baglaenko Y, Mu Z, Curtis M, et al. Precisely defining disease variant effects in CRISPR-edited single cells. Nature. 2025. doi:10.1038/s41586-025-09313-3

Phosphorylation-Inducing Molecules for Regulating Dynamic Cellular Processes.

Pergu R, Sreekanth V, Kokkonda P, et al. Phosphorylation-Inducing Molecules for Regulating Dynamic Cellular Processes. Journal of the American Chemical Society. 2025;147(29):25316-25324. doi:10.1021/jacs.5c04275

Bering: joint cell segmentation and annotation for spatial transcriptomics with transferred graph embeddings.

Jin K, Zhang Z, Zhang K, et al. Bering: joint cell segmentation and annotation for spatial transcriptomics with transferred graph embeddings. Nature communications. 2025;16(1):6618. doi:10.1038/s41467-025-60898-9

Regulation of inflammatory responses by pH-dependent transcriptional condensates.

Wu Z, Pope SD, Ahmed NS, et al. Regulation of inflammatory responses by pH-dependent transcriptional condensates. Cell. 2025. doi:10.1016/j.cell.2025.06.033

nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome.

Dagher M, Ongo G, Robichaud N, et al. nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2023.04.17.535914

Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2-mutated post-MPN AML.

Wang Z, Skwarska A, Poigaialwar G, et al. Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2-mutated post-MPN AML. Blood. 2025;146(3):341-355. doi:10.1182/blood.2024027117

The Somatic Mosaicism across Human Tissues Network.

Coorens THH, Oh JW, Choi YA, et al. The Somatic Mosaicism across Human Tissues Network. Nature. 2025;643(8070):47-59. doi:10.1038/s41586-025-09096-7

FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses.

Kim C, Gabriel KR, Boone D, et al. FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses. Science advances. 2025;11(27):eadu9104. doi:10.1126/sciadv.adu9104

Optogenetics-enabled discovery of integrated stress response modulators.

Wong F, Li A, Omori S, et al. Optogenetics-enabled discovery of integrated stress response modulators. Cell. 2025. doi:10.1016/j.cell.2025.06.024

Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease.

Kim H, Nelson P, Nzabarushimana E, et al. Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease. Nature metabolism. 2025. doi:10.1038/s42255-025-01318-6