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Publications

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma.

Miao D, Margolis CA, Gao W, et al. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science. 2018;359(6377):801-806. doi:10.1126/science.aan5951

Editing the Genome Without Double-Stranded DNA Breaks.

Komor AC, Badran AH, Liu DR. Editing the Genome Without Double-Stranded DNA Breaks. ACS Chem Biol. 2018;13(2):383-388. doi:10.1021/acschembio.7b00710

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.

Minton DR, Nam M, McLaughlin DJ, et al. Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Mol Cell. 2018;69(4):610-621.e5. doi:10.1016/j.molcel.2018.01.024

Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells.

Chen PY, Muzumdar MD, Dorans KJ, et al. Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells. Cancer Res. 2018;78(4):985-1002. doi:10.1158/0008-5472.CAN-17-2129

A community approach to mortality prediction in sepsis via gene expression analysis.

Sweeney TE, Perumal TM, Henao R, et al. A community approach to mortality prediction in sepsis via gene expression analysis. Nat Commun. 2018;9(1):694. doi:10.1038/s41467-018-03078-2

ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors.

Terai H, Kitajima S, Potter DS, et al. ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors. Cancer Res. 2018;78(4):1044-1057. doi:10.1158/0008-5472.CAN-17-1904

Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN.

Elf S, Abdelfattah NS, Baral AJ, et al. Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN. Blood. 2018;131(7):782-786. doi:10.1182/blood-2017-08-800896

Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study.

Razquin C, Liang L, Toledo E, et al. Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study. Int J Cardiol. 2018;253:126-132. doi:10.1016/j.ijcard.2017.10.026

GDC-0879, a BRAF Inhibitor, Protects Kidney Podocytes from Death.

Sieber J, Wieder N, Clark A, et al. GDC-0879, a BRAF Inhibitor, Protects Kidney Podocytes from Death. Cell Chem Biol. 2018;25(2):175-184.e4. doi:10.1016/j.chembiol.2017.11.006

diffloop: a computational framework for identifying and analyzing differential DNA loops from sequencing data.

Lareau CA, Aryee MJ. diffloop: a computational framework for identifying and analyzing differential DNA loops from sequencing data. Bioinformatics. 2018;34(4):672-674. doi:10.1093/bioinformatics/btx623