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Publications

Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.

Duvall JR, Bedard L, Naylor-Olsen AM, et al. Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile. ACS Infect Dis. 2017;3(5):349-359. doi:10.1021/acsinfecdis.6b00206

Heterosis as a consequence of regulatory incompatibility.

Herbst RH, Bar-Zvi D, Reikhav S, et al. Heterosis as a consequence of regulatory incompatibility. BMC Biol. 2017;15(1):38. doi:10.1186/s12915-017-0373-7

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.

Merkle FT, Ghosh S, Kamitaki N, et al. Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature. 2017;545(7653):229-233. doi:10.1038/nature22312

Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants.

Karnes JH, Bastarache L, Shaffer CM, et al. Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants. Sci Transl Med. 2017;9(389). doi:10.1126/scitranslmed.aai8708

CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors.

Ma Y, Walsh MJ, Bernhardt K, et al. CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors. Cell Host Microbe. 2017;21(5):580-591.e7. doi:10.1016/j.chom.2017.04.005

Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases.

Ananthakrishnan AN, Luo C, Yajnik V, et al. Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases. Cell Host Microbe. 2017;21(5):603-610.e3. doi:10.1016/j.chom.2017.04.010

Control of type III protein secretion using a minimal genetic system.

Song M, Sukovich DJ, Ciccarelli L, et al. Control of type III protein secretion using a minimal genetic system. Nat Commun. 2017;8:14737. doi:10.1038/ncomms14737

Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease.

Friesen M, Camahort R, Lee YK, et al. Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease. Stem Cell Reports. 2017;8(5):1164-1173. doi:10.1016/j.stemcr.2017.03.014

Challenges and emerging directions in single-cell analysis.

Yuan GC, Cai L, Elowitz M, et al. Challenges and emerging directions in single-cell analysis. Genome Biol. 2017;18(1):84. doi:10.1186/s13059-017-1218-y

International Cooperation to Enable the Diagnosis of All Rare Genetic Diseases.

Boycott KM, Rath A, Chong JX, et al. International Cooperation to Enable the Diagnosis of All Rare Genetic Diseases. Am J Hum Genet. 2017;100(5):695-705. doi:10.1016/j.ajhg.2017.04.003