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Publications

Targeting heterogeneous tumor microenvironments in pancreatic cancer mouse models of metastasis by TGF-β depletion.

Chen SY, Kung HC, Espinoza B, et al. Targeting heterogeneous tumor microenvironments in pancreatic cancer mouse models of metastasis by TGF-β depletion. JCI insight. 2024;9(21). doi:10.1172/jci.insight.182766

Methylation Mesa define functional regulatory elements for targeted gene activation.

Liu Y V, Suryatenggara J, Wong H, et al. Methylation Mesa define functional regulatory elements for targeted gene activation. Research square. 2024. doi:10.21203/rs.3.rs-4359582/v1

Cell Populations in Human Breast Cancers are Molecularly and Biologically Distinct with Age.

Parsons A, Colon ES, Spasic M, et al. Cell Populations in Human Breast Cancers are Molecularly and Biologically Distinct with Age. Research square. 2024. doi:10.21203/rs.3.rs-5167339/v1

Deep Learning-Based Detection of Carotid Plaques Informs Cardiovascular Risk Prediction and Reveals Genetic Drivers of Atherosclerosis.

Omarov M, Zhang L, Jorshery SD, et al. Deep Learning-Based Detection of Carotid Plaques Informs Cardiovascular Risk Prediction and Reveals Genetic Drivers of Atherosclerosis. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.10.17.24315675

Safety and implementation of a phase 1 randomized GLA-SE-adjuvanted CH505TF gp120 HIV vaccine trial in newborns.

Violari A, Otwombe K, Hahn W, et al. Safety and implementation of a phase 1 randomized GLA-SE-adjuvanted CH505TF gp120 HIV vaccine trial in newborns. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.10.15.24315548

K-mer analysis of long-read alignment pileups for structural variant genotyping.

English AC, Cunial F, Metcalf GA, Gibbs RA, Sedlazeck FJ. K-mer analysis of long-read alignment pileups for structural variant genotyping. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.22.619642

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.

Kwon JJ, Dilly J, Liu S, et al. Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.22.618529

Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis.

Jones MG, Sun D, Min KHJ, et al. Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.21.619529

A framework for target discovery in rare cancers.

Li B, Sadagopan A, Li J, et al. A framework for target discovery in rare cancers. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.24.620074

Evolutionary-Scale Enzymology Enables Biochemical Constant Prediction Across a Multi-Peaked Catalytic Landscape.

Muir DF, Asper GPR, Notin P, et al. Evolutionary-Scale Enzymology Enables Biochemical Constant Prediction Across a Multi-Peaked Catalytic Landscape. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.23.619915