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Publications

Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo.

An M, Raguram A, Du SW, et al. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology. 2024. doi:10.1038/s41587-023-02078-y

Bringing computation to biology by bridging the last mile.

Carpenter AE, Singh S. Bringing computation to biology by bridging the last mile. Nature cell biology. 2024;26(1):5-7. doi:10.1038/s41556-023-01286-7

METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.

Ast T, Itoh Y, Sadre S, et al. METTL17 is an Fe-S cluster checkpoint for mitochondrial translation. Molecular cell. 2024. doi:10.1016/j.molcel.2023.12.016

Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma.

Hamel AR, Yan W, Rouhana JM, et al. Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nature communications. 2024;15(1):396. doi:10.1038/s41467-023-44380-y

Distinct and shared genetic architectures of gestational diabetes mellitus and type 2 diabetes.

Elliott A, Walters RK, Pirinen M, et al. Distinct and shared genetic architectures of gestational diabetes mellitus and type 2 diabetes. Nature genetics. 2024. doi:10.1038/s41588-023-01607-4

Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA.

Kobayashi-Kirschvink KJ, Comiter CS, Gaddam S, et al. Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA. Nature biotechnology. 2024. doi:10.1038/s41587-023-02082-2

Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway.

Grote A, Piscon B, Manson AL, et al. Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway. Cell host & microbe. 2024;32(1):79-92.e7. doi:10.1016/j.chom.2023.12.001

Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies.

Martin-Alonso C, Tabrizi S, Xiong K, et al. Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies. Science (New York, N.Y.). 2024;383(6680):eadf2341. doi:10.1126/science.adf2341

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.

Wheeler EC, Martin BJE, Doyle WC, et al. Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML. Science translational medicine. 2024;16(728):eade2774. doi:10.1126/scitranslmed.ade2774

Integrative genotyping of cancer and immune phenotypes by long-read sequencing.

Penter L, Borji M, Nagler A, et al. Integrative genotyping of cancer and immune phenotypes by long-read sequencing. Nature communications. 2024;15(1):32. doi:10.1038/s41467-023-44137-7