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Publications

Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons.

Kumar SS, Naseri NN, Pather SR, et al. Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Science advances. 2024;10(6):eadj4767. doi:10.1126/sciadv.adj4767

PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells.

Lebon D, Collet L, Djordjevic S, et al. PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells. Cancer medicine. 2024;13(2):e6984. doi:10.1002/cam4.6984

Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia.

Mondal AK, Brock DC, Rowan S, et al. Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia. iScience. 2024;27(2):108979. doi:10.1016/j.isci.2024.108979

The genetic basis of autoimmunity seen through the lens of T cell functional traits.

Lagattuta KA, Park HL, Rumker L, Ishigaki K, Nathan A, Raychaudhuri S. The genetic basis of autoimmunity seen through the lens of T cell functional traits. Nature communications. 2024;15(1):1204. doi:10.1038/s41467-024-45170-w

Medieval DNA from Soqotra points to Eurasian origins of an isolated population at the crossroads of Africa and Arabia.

Sirak K, Van Rensburg JJ, Brielle E, et al. Medieval DNA from Soqotra points to Eurasian origins of an isolated population at the crossroads of Africa and Arabia. Nature ecology & evolution. 2024. doi:10.1038/s41559-024-02322-x

The single-cell transcriptome program of nodule development cellular lineages in Medicago truncatula.

Pereira WJ, Boyd J, Conde D, et al. The single-cell transcriptome program of nodule development cellular lineages in Medicago truncatula. Cell reports. 2024;43(2):113747. doi:10.1016/j.celrep.2024.113747

Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase.

Maw JJ, Coker JA, Arya T, et al. Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase. Journal of medicinal chemistry. 2024. doi:10.1021/acs.jmedchem.3c01807

Glycan-costumed virus-like particles promote type 1 anti-tumor immunity.

Lensch V, Gabba A, Hincapie R, et al. Glycan-costumed virus-like particles promote type 1 anti-tumor immunity. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.01.18.575711

Mitochondrial dysfunction in Spaceflight Associated Neuro-Ocular Syndrome (SANS): a molecular hypothesis in pathogenesis.

Waisberg E, Ong J, Masalkhi M, Mao XW, Beheshti A, Lee AG. Mitochondrial dysfunction in Spaceflight Associated Neuro-Ocular Syndrome (SANS): a molecular hypothesis in pathogenesis. Eye (London, England). 2024. doi:10.1038/s41433-024-02951-3

Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.

Kotliar D, Raju S, Tabrizi S, et al. Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever. Nature microbiology. 2024. doi:10.1038/s41564-023-01589-3