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Publications

High-dimensional phenotyping to define the genetic basis of cellular morphology.

Tegtmeyer M, Arora J, Asgari S, et al. High-dimensional phenotyping to define the genetic basis of cellular morphology. Nature communications. 2024;15(1):347. doi:10.1038/s41467-023-44045-w

A comprehensive analysis of clinical and polygenic germline influences on somatic mutational burden.

Taraszka K, Groha S, King D, et al. A comprehensive analysis of clinical and polygenic germline influences on somatic mutational burden. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2023.12.010

Public platform with 39,472 exome control samples enables association studies without genotype sharing.

Artomov M, Loboda AA, Artyomov MN, Daly MJ. Public platform with 39,472 exome control samples enables association studies without genotype sharing. Nature genetics. 2024. doi:10.1038/s41588-023-01637-y

Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo.

An M, Raguram A, Du SW, et al. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology. 2024. doi:10.1038/s41587-023-02078-y

Bringing computation to biology by bridging the last mile.

Carpenter AE, Singh S. Bringing computation to biology by bridging the last mile. Nature cell biology. 2024;26(1):5-7. doi:10.1038/s41556-023-01286-7

METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.

Ast T, Itoh Y, Sadre S, et al. METTL17 is an Fe-S cluster checkpoint for mitochondrial translation. Molecular cell. 2024. doi:10.1016/j.molcel.2023.12.016

Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma.

Hamel AR, Yan W, Rouhana JM, et al. Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nature communications. 2024;15(1):396. doi:10.1038/s41467-023-44380-y

Distinct and shared genetic architectures of gestational diabetes mellitus and type 2 diabetes.

Elliott A, Walters RK, Pirinen M, et al. Distinct and shared genetic architectures of gestational diabetes mellitus and type 2 diabetes. Nature genetics. 2024. doi:10.1038/s41588-023-01607-4

Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA.

Kobayashi-Kirschvink KJ, Comiter CS, Gaddam S, et al. Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA. Nature biotechnology. 2024. doi:10.1038/s41587-023-02082-2

Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway.

Grote A, Piscon B, Manson AL, et al. Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway. Cell host & microbe. 2024;32(1):79-92.e7. doi:10.1016/j.chom.2023.12.001