ӳ��ý

Publications

Whole-genome long-read sequencing downsampling and its effect on variant-calling precision and recall.

Harvey WT, Ebert P, Ebler J, et al. Whole-genome long-read sequencing downsampling and its effect on variant-calling precision and recall. Genome research. 2023;33(12):2029-2040. doi:10.1101/gr.278070.123

Biomarker changes preceding symptom onset in genetic prion disease.

Vallabh SM, Mortberg MA, Allen SW, et al. Biomarker changes preceding symptom onset in genetic prion disease. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.12.18.23300042

Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease.

Lin J, Mars N, Fu Y, et al. Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease. JACC. Basic to translational science. 2023;8(12):1489-1499. doi:10.1016/j.jacbts.2023.07.006

Improving Polygenic Risk Scores for Coronary Artery Disease: What Helps and by How Much?

Ajufo EC, Aragam KG. Improving Polygenic Risk Scores for Coronary Artery Disease: What Helps and by How Much? JACC. Basic to translational science. 2023;8(12):1500-1502. doi:10.1016/j.jacbts.2023.10.005

Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model.

Iorgulescu B, Ruthen N, Ahn R, et al. Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model. Frontiers in immunology. 2023;14:1297932. doi:10.3389/fimmu.2023.1297932

MAESTRO-Pool Enables Highly Parallel and Specific Mutation-Enrichment Sequencing for Minimal Residual Disease Detection in Cohort Studies.

Blewett T, Rhoades J, Liu R, et al. MAESTRO-Pool Enables Highly Parallel and Specific Mutation-Enrichment Sequencing for Minimal Residual Disease Detection in Cohort Studies. Clinical chemistry. 2023. doi:10.1093/clinchem/hvad203

Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers.

Dufva O, Gandolfi S, Huuhtanen J, et al. Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers. Immunity. 2023;56(12):2816-2835.e13. doi:10.1016/j.immuni.2023.11.008

Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses.

Normandin E, Triana S, Raju SS, et al. Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses. Cell genomics. 2023;3(12):100440. doi:10.1016/j.xgen.2023.100440

Discovery of a structural class of antibiotics with explainable deep learning.

Wong F, Zheng EJ, Valeri JA, et al. Discovery of a structural class of antibiotics with explainable deep learning. Nature. 2023. doi:10.1038/s41586-023-06887-8

Proteolysis-targeting chimeras with reduced off-targets.

Nguyen TM, Sreekanth V, Deb A, et al. Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry. 2023. doi:10.1038/s41557-023-01379-8