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Publications

Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells.

Yang J, Vamvini M, Nigro P, et al. Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells. Cell Metab. 2022;34(10):1578-1593.e6. doi:10.1016/j.cmet.2022.09.004

Multiscale profiling of protease activity in cancer.

Amini AP, Kirkpatrick JD, Wang CS, et al. Multiscale profiling of protease activity in cancer. Nat Commun. 2022;13(1):5745. doi:10.1038/s41467-022-32988-5

Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements.

Battaglia S, Dong K, Wu J, et al. Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements. Nat Genet. 2022;54(10):1504-1513. doi:10.1038/s41588-022-01188-8

In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer.

Dubrot J, Du PP, Lane-Reticker SK, et al. In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer. Nat Immunol. 2022;23(10):1495-1506. doi:10.1038/s41590-022-01315-x

COVID-19 Exposure Assessment Tool (CEAT): Exposure quantification based on ventilation, infection prevalence, group characteristics, and behavior.

Schimmoller BJ, Trovão NS, Isbell M, et al. COVID-19 Exposure Assessment Tool (CEAT): Exposure quantification based on ventilation, infection prevalence, group characteristics, and behavior. Sci Adv. 2022;8(39):eabq0593. doi:10.1126/sciadv.abq0593

High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs.

Huang TP, Heins ZJ, Miller SM, et al. High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01410-2

Methionine metabolism controls the B cell EBV epigenome and viral latency.

Guo R, Liang JH, Zhang Y, et al. Methionine metabolism controls the B cell EBV epigenome and viral latency. Cell Metab. 2022;34(9):1280-1297.e9. doi:10.1016/j.cmet.2022.08.008

Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models.

Susco SG, Ghosh S, Mazzucato P, et al. Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models. Cell Rep. 2022;40(10):111312. doi:10.1016/j.celrep.2022.111312

Virtual screening for small-molecule pathway regulators by image-profile matching.

Rohban MH, Fuller AM, Tan C, et al. Virtual screening for small-molecule pathway regulators by image-profile matching. Cell Syst. 2022. doi:10.1016/j.cels.2022.08.003

Cell type-specific inference of differential expression in spatial transcriptomics.

Cable DM, Murray E, Shanmugam V, et al. Cell type-specific inference of differential expression in spatial transcriptomics. Nat Methods. 2022. doi:10.1038/s41592-022-01575-3