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Publications

STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer.

Ding L, Wang Q, Martincuks A, et al. STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer. Journal for immunotherapy of cancer. 2023;11(1). doi:10.1136/jitc-2022-005627

Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank.

Vlasschaert C, Heimlich B, Rauh MJ, Natarajan P, Bick AG. Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank. Circulation. 2023;147(4):358-360. doi:10.1161/CIRCULATIONAHA.122.062126

Reanalysis of clinical exome identifies the second variant in two individuals with recessive disorders.

Li Q, Agrawal R, Schmitz-Abe K, et al. Reanalysis of clinical exome identifies the second variant in two individuals with recessive disorders. European journal of human genetics : EJHG. 2023. doi:10.1038/s41431-023-01291-2

Bayesian mixed model analysis uncovered 21 risk loci for chronic kidney disease in boxer dogs.

Lingaas F, Tengvall K, Jansen JH, et al. Bayesian mixed model analysis uncovered 21 risk loci for chronic kidney disease in boxer dogs. PLoS genetics. 2023;19(1):e1010599. doi:10.1371/journal.pgen.1010599

Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening.

Tan J, Shenker-Tauris N, Rodriguez-Hernaez J, et al. Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening. Nature biotechnology. 2023. doi:10.1038/s41587-022-01612-8

Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity.

Rajagopal VM, Ganna A, Coleman JRI, et al. Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity. Scientific reports. 2023;13(1):429. doi:10.1038/s41598-022-26845-0

Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome.

Parry EM, Leshchiner I, Guièze R, et al. Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nature medicine. 2023;29(1):158-169. doi:10.1038/s41591-022-02113-6

Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury.

Stein MB, Jain S, Parodi L, et al. Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury. Translational psychiatry. 2023;13(1):24. doi:10.1038/s41398-023-02313-9

Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens.

Wang Y, Fan JL, Melms JC, et al. Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens. Nature genetics. 2023;55(1):19-25. doi:10.1038/s41588-022-01268-9

Telomerase inhibition is an effective therapeutic strategy in TERT promoter mutant-glioblastoma models with low tumor volume.

Aquilanti E, Kageler L, Watson J, et al. Telomerase inhibition is an effective therapeutic strategy in TERT promoter mutant-glioblastoma models with low tumor volume. Neuro-oncology. 2023. doi:10.1093/neuonc/noad024