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Publications

Identification of Natural CRISPR Systems and Targets in the Human Microbiome.

Münch PC, Franzosa EA, Stecher B, McHardy AC, Huttenhower C. Identification of Natural CRISPR Systems and Targets in the Human Microbiome. Cell Host Microbe. 2020. doi:10.1016/j.chom.2020.10.010

Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER Metastatic Breast Cancer.

Mao P, Cohen O, Kowalski KJ, et al. Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER Metastatic Breast Cancer. Clin Cancer Res. 2020;26(22):5974-5989. doi:10.1158/1078-0432.CCR-19-3958

Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants.

Iqbal S, Pérez-Palma E, Jespersen JB, et al. Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants. Proc Natl Acad Sci U S A. 2020;117(45):28201-28211. doi:10.1073/pnas.2002660117

A Systematic Protein Turnover Map for Decoding Protein Degradation.

Christiano R, Arlt H, Kabatnik S, et al. A Systematic Protein Turnover Map for Decoding Protein Degradation. Cell Rep. 2020;33(6):108378. doi:10.1016/j.celrep.2020.108378

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41.

Carey KL, Paulus GLC, Wang L, et al. TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41. Cell Rep. 2020;33(6):108371. doi:10.1016/j.celrep.2020.108371

COVID-19 and Cancer: Current Challenges and Perspectives.

Bakouny Z, Hawley JE, Choueiri TK, et al. COVID-19 and Cancer: Current Challenges and Perspectives. Cancer Cell. 2020;38(5):629-646. doi:10.1016/j.ccell.2020.09.018

Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis.

Chitraju C, Fischer AW, Farese RV, Walther TC. Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis. Cell Rep. 2020;33(5):108348. doi:10.1016/j.celrep.2020.108348

Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity.

Kinker GS, Greenwald AC, Tal R, et al. Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity. Nat Genet. 2020;52(11):1208-1218. doi:10.1038/s41588-020-00726-6

A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells.

Yang K, Lee M, Jones PA, et al. A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells. Sci Adv. 2020;6(47). doi:10.1126/sciadv.abc3207

A comparative genomics multitool for scientific discovery and conservation.

Zoonomia Consortium. A comparative genomics multitool for scientific discovery and conservation. Nature. 2020;587(7833):240-245. doi:10.1038/s41586-020-2876-6