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Publications

Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions.

Kelly RS, Sordillo JE, Lutz SM, et al. Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions. Metabolites. 2019;9(9). doi:10.3390/metabo9090179

Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior.

Ganna A, Verweij KJH, Nivard MG, et al. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior. Science. 2019;365(6456). doi:10.1126/science.aat7693

Influence of agricultural antibiotic use on chicken meat-associated enterococci and their connection to the clinic.

Manson AL, Van Tyne D, Straub TJ, et al. Influence of agricultural antibiotic use on chicken meat-associated enterococci and their connection to the clinic. Appl Environ Microbiol. 2019. doi:10.1128/AEM.01559-19

CHIPing away at breast cancer.

Sperling AS, Ebert BL. CHIPing away at breast cancer. J Natl Cancer Inst. 2019. doi:10.1093/jnci/djz158

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.

Oberlick EM, Rees MG, Seashore-Ludlow B, et al. Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Rep. 2019;28(9):2331-2344.e8. doi:10.1016/j.celrep.2019.07.021

Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate.

Lopatkin AJ, Stokes JM, Zheng EJ, et al. Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate. Nat Microbiol. 2019. doi:10.1038/s41564-019-0536-0

Programmable CRISPR-responsive smart materials.

English MA, Soenksen LR, Gayet RV, et al. Programmable CRISPR-responsive smart materials. Science. 2019;365(6455):780-785. doi:10.1126/science.aaw5122

Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships.

Plichta DR, Graham DB, Subramanian S, Xavier RJ. Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships. Cell. 2019;178(5):1041-1056. doi:10.1016/j.cell.2019.07.045

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.

Etchegaray JP, Zhong L, Li C, et al. The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. Mol Cell. 2019;75(4):683-699.e7. doi:10.1016/j.molcel.2019.06.034

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.

Cheng CW, Biton M, Haber AL, et al. Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet. Cell. 2019;178(5):1115-1131.e15. doi:10.1016/j.cell.2019.07.048