Dickinson BC, Packer MS, Badran AH, Liu DR. A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations. Nat Commun. 2014;5:5352. doi:10.1038/ncomms6352
Carlson JC, Badran AH, Guggiana-Nilo DA, Liu DR. Negative selection and stringency modulation in phage-assisted continuous evolution. Nat Chem Biol. 2014;10(3):216-22. doi:10.1038/nchembio.1453
Ataman B, Boulting GL, Harmin DA, et al. Evolution of Osteocrin as an activity-regulated factor in the primate brain. Nature. 2016;539(7628):242-247. doi:10.1038/nature20111
Curtis EA, Liu DR. A naturally occurring, noncanonical GTP aptamer made of simple tandem repeats. RNA Biol. 2014;11(6):682-92.
Dickinson BC, Leconte AM, Allen B, Esvelt KM, Liu DR. Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution. Proc Natl Acad Sci U S A. 2013;110(22):9007-12. doi:10.1073/pnas.1220670110
Leconte AM, Dickinson BC, Yang DD, Chen IA, Allen B, Liu DR. A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes. Biochemistry. 2013;52(8):1490-9. doi:10.1021/bi3016185
Yuen CM, Liu DR. Dissecting protein structure and function using directed evolution. Nat Methods. 2007;4(12):995-7. doi:10.1038/nmeth1207-995
Doyon JB, Pattanayak V, Meyer CB, Liu DR. Directed evolution and substrate specificity profile of homing endonuclease I-SceI. J Am Chem Soc. 2006;128(7):2477-84. doi:10.1021/ja057519l
Calderone CT, Liu DR. Nucleic-acid-templated synthesis as a model system for ancient translation. Curr Opin Chem Biol. 2004;8(6):645-53. doi:10.1016/j.cbpa.2004.09.003
Bittker JA, Le BV, Liu DR. Nucleic acid evolution and minimization by nonhomologous random recombination. Nat Biotechnol. 2002;20(10):1024-9. doi:10.1038/nbt736