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Gene Regulation Observatory
Kim KL, Rahme GJ, Goel VY, Farran CAE, Hansen AS, Bernstein BE. Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation. Molecular cell. 2024. doi:10.1016/j.molcel.2024.02.007
Ryu J, Barkal S, Yu T, et al. Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification. Nature genetics. 2024. doi:10.1038/s41588-024-01726-6
Schiroli G, Kartha V, Duarte FM, et al. Cell of origin epigenetic priming determines susceptibility to Tet2 mutation. Nature communications. 2024;15(1):4325. doi:10.1038/s41467-024-48508-6
Pan W, Zhang W, Zheng B, et al. Cellular dynamics in pig-to-human kidney xenotransplantation. Med (New York, N.Y.). 2024. doi:10.1016/j.medj.2024.05.003
Weng LC, Khurshid S, Hall AW, et al. Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias. Circulation. Genomic and precision medicine. 2024:e004320. doi:10.1161/CIRCGEN.123.004320
Nemsick S, Hansen AS. Molecular models of bidirectional promoter regulation. Current opinion in structural biology. 2024;87:102865. doi:10.1016/j.sbi.2024.102865
Do C, Jiang G, Cova G, et al. Brain and cancer associated binding domain mutations provide insight into CTCF’s relationship with chromatin and its ability to act as a chromatin organizer. Research square. 2024. doi:10.21203/rs.3.rs-4670379/v1
Tervi A, Ramste M, Abner E, et al. Genetic and functional analysis of Raynaud’s syndrome implicates loci in vasculature and immunity. Cell genomics. 2024:100630. doi:10.1016/j.xgen.2024.100630
Schlissel G, Meziane M, Narducci D, Hansen AS, Li P. Diffusion barriers imposed by tissue topology shape Hedgehog morphogen gradients. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(36):e2400677121. doi:10.1073/pnas.2400677121