ӳ��ý

Gene Regulation Observatory

Refining the cis-regulatory grammar learned by sequence-to-activity models by increasing model resolution.

Chandra NA, Hu Y, Buenrostro JD, Mostafavi S, Sasse A. Refining the cis-regulatory grammar learned by sequence-to-activity models by increasing model resolution. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.24.634804

Genome-wide absolute quantification of chromatin looping.

Jusuf JM, Grosse-Holz S, Gabriele M, et al. Genome-wide absolute quantification of chromatin looping. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.13.632736

Characterization of tumour heterogeneity through segmentation-free representation learning on multiplexed imaging data.

Tan J, Le H, Deng J, et al. Characterization of tumour heterogeneity through segmentation-free representation learning on multiplexed imaging data. Nature biomedical engineering. 2025. doi:10.1038/s41551-025-01348-1

Multi-locus CRISPRi targeting with a single truncated guide RNA.

Moore MM, Wekhande S, Issner R, et al. Multi-locus CRISPRi targeting with a single truncated guide RNA. Nature communications. 2025;16(1):1357. doi:10.1038/s41467-025-56144-x

A multi-modal transformer for cell type-agnostic regulatory predictions.

Javed N, Weingarten T, Sehanobish A, et al. A multi-modal transformer for cell type-agnostic regulatory predictions. Cell genomics. 2025:100762. doi:10.1016/j.xgen.2025.100762

Multiscale footprints reveal the organization of cis-regulatory elements.

Hu Y, Horlbeck MA, Zhang R, et al. Multiscale footprints reveal the organization of cis-regulatory elements. Nature. 2025. doi:10.1038/s41586-024-08443-4

The impact of common and rare genetic variants on bradyarrhythmia development.

Weng LC, Rämö JT, Jurgens SJ, et al. The impact of common and rare genetic variants on bradyarrhythmia development. Nature genetics. 2025. doi:10.1038/s41588-024-01978-2

Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart.

Ma R, Conley SD, Kosicki M, et al. Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.11.20.24317557

Single cell variant to enhancer to gene map for coronary artery disease.

Amrute JM, Lee PC, Eres I, et al. Single cell variant to enhancer to gene map for coronary artery disease. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.11.13.24317257

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas.

Wu J, Castro NG, Battaglia S, et al. Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas. Nature cancer. 2024. doi:10.1038/s43018-024-00865-3