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Metabolomics Platform

Lipid Profiles and Heart Failure Risk: Results From Two Prospective Studies.

Wittenbecher C, Eichelmann F, Toledo E, et al. Lipid Profiles and Heart Failure Risk: Results From Two Prospective Studies. Circulation research. 2021;128(3):309-320. doi:10.1161/CIRCRESAHA.120.317883

Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women.

Zeleznik OA, Balasubramanian R, Zhao Y, et al. Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women. NPJ breast cancer. 2021;7(1):54. doi:10.1038/s41523-021-00262-4

Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease.

Guasch-Ferré M, Hernández-Alonso P, Drouin-Chartier JP, et al. Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease. The Journal of nutrition. 2021;151(2):303-311. doi:10.1093/jn/nxaa374

Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis.

Ilboudo Y, Garrett ME, Bartolucci P, et al. Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis. Blood cells, molecules & diseases. 2021;86:102504. doi:10.1016/j.bcmd.2020.102504

Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.

Sharma R, Reinstadler B, Engelstad K, et al. Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity. The Journal of clinical investigation. 2021;131(2). doi:10.1172/JCI136055

Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study.

Papandreou C, Bulló M, Hernández-Alonso P, et al. Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. Clinical chemistry. 2021;67(1):288-297. doi:10.1093/clinchem/hvaa224

Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines.

Smith SA, Ogawa SA, Chau L, et al. Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines. The Journal of clinical investigation. 2021;131(1). doi:10.1172/JCI133371

Plasma Metabolomic Profiles of Glycemic Index, Glycemic Load, and Carbohydrate Quality Index in the PREDIMED Study.

Bulló M, Papandreou C, Ruiz-Canela M, et al. Plasma Metabolomic Profiles of Glycemic Index, Glycemic Load, and Carbohydrate Quality Index in the PREDIMED Study. The Journal of nutrition. 2021;151(1):50-58. doi:10.1093/jn/nxaa345

Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1.

Tsai PY, Lee MS, Jadhav U, et al. Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(10). doi:10.1073/pnas.2003014118

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.

Taliun D, Harris DN, Kessler MD, et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021;590(7845):290-299. doi:10.1038/s41586-021-03205-y