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Metabolomics Platform

Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis.

Bjornevik K, O’Reilly ÉJ, Berry JD, et al. Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis. Neurology. 2019;92(18):e2081-e2088. doi:10.1212/WNL.0000000000006669

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.

Zou Y, Palte MJ, Deik AA, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat Commun. 2019;10(1):1617. doi:10.1038/s41467-019-09277-9

Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD Recycling.

Kim W, Deik A, Gonzalez C, et al. Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD Recycling. Cell Metab. 2019;29(4):856-870.e7. doi:10.1016/j.cmet.2018.12.023

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning S, Haque A, Imberdis T, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019;73(5):1001-1014.e8. doi:10.1016/j.molcel.2018.11.028

Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.

Yu E, Ruiz-Canela M, Razquin C, et al. Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial. Diabetes Obes Metab. 2019;21(2):397-401. doi:10.1111/dom.13514

Gut microbiome structure and metabolic activity in inflammatory bowel disease.

Franzosa EA, Sirota-Madi A, Avila-Pacheco J, et al. Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat Microbiol. 2019;4(2):293-305. doi:10.1038/s41564-018-0306-4

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.

Chao CC, Gutiérrez-Vázquez C, Rothhammer V, et al. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019;179(7):1483-1498.e22. doi:10.1016/j.cell.2019.11.016

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.

Luengo A, Abbott KL, Davidson SM, et al. Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer. Nature communications. 2019;10(1):5604. doi:10.1038/s41467-019-13419-4

Association of Lipidomic Profiles With Progression of Carotid Artery Atherosclerosis in HIV Infection.

Chai JC, Deik AA, Hua S, et al. Association of Lipidomic Profiles With Progression of Carotid Artery Atherosclerosis in HIV Infection. JAMA cardiology. 2019;4(12):1239-1249. doi:10.1001/jamacardio.2019.4025

Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program.

Chen ZZ, Liu J, Morningstar J, et al. Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program. Diabetes. 2019;68(12):2337-2349. doi:10.2337/db19-0236