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Metabolomics Platform

Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis.

Bjornevik K, O’Reilly Éilis J, Berry JD, et al. Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis. Neurology. 2019;92(18):e2081-e2088. doi:10.1212/WNL.0000000000006669

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.

Zou Y, Palte MJ, Deik AA, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat Commun. 2019;10(1):1617. doi:10.1038/s41467-019-09277-9

Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD Recycling.

Kim W, Deik A, Gonzalez C, et al. Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD Recycling. Cell Metab. 2019;29(4):856-870.e7. doi:10.1016/j.cmet.2018.12.023

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning S, Haque A, Imberdis T, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019;73(5):1001-1014.e8. doi:10.1016/j.molcel.2018.11.028

Gut microbiome structure and metabolic activity in inflammatory bowel disease.

Franzosa EA, Sirota-Madi A, Avila-Pacheco J, et al. Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat Microbiol. 2019;4(2):293-305. doi:10.1038/s41564-018-0306-4

Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.

Yu E, Ruiz-Canela M, Razquin C, et al. Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial. Diabetes Obes Metab. 2019;21(2):397-401. doi:10.1111/dom.13514

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.

Chao CC, Gutiérrez-Vázquez C, Rothhammer V, et al. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019;179(7):1483-1498.e22. doi:10.1016/j.cell.2019.11.016

The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

Yu B, Zanetti KA, Temprosa M, et al. The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. American journal of epidemiology. 2019;188(6):991-1012. doi:10.1093/aje/kwz028

Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies.

Razquin C, Ruiz-Canela M, Clish CB, et al. Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies. Cardiovascular diabetology. 2019;18(1):151. doi:10.1186/s12933-019-0958-2

Elevated Plasma Ceramides Are Associated With Antiretroviral Therapy Use and Progression of Carotid Artery Atherosclerosis in HIV Infection.

Zhao W, Wang X, Deik AA, et al. Elevated Plasma Ceramides Are Associated With Antiretroviral Therapy Use and Progression of Carotid Artery Atherosclerosis in HIV Infection. Circulation. 2019;139(17):2003-2011. doi:10.1161/CIRCULATIONAHA.118.037487