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Metabolomics Platform

Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension.

Rhee EP, Clish CB, Pierce KA, Saad A, Lerman LO, Textor SC. Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension. J Hypertens. 2015;33(4):836-42. doi:10.1097/HJH.0000000000000470

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.

Kostic AD, Gevers D, Siljander H, et al. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe. 2015;17(2):260-73. doi:10.1016/j.chom.2015.01.001

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.

Palsson-McDermott EM, Curtis AM, Goel G, et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21(1):65-80. doi:10.1016/j.cmet.2014.12.005

Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis.

Priolo C, Ricoult SJH, Khabibullin D, et al. Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology. 2015;53(1):33-41. doi:10.1165/rcmb.2014-0379RC

Metabolomic profiling in the prediction of gestational diabetes mellitus.

Bentley-Lewis R, Huynh J, Xiong G, et al. Metabolomic profiling in the prediction of gestational diabetes mellitus. Diabetologia. 2015;58(6):1329-32. doi:10.1007/s00125-015-3553-4

Erratum: Distinct metabolomic signatures are associated with longevity in humans.

Cheng S, Larson MG, McCabe EL, et al. Erratum: Distinct metabolomic signatures are associated with longevity in humans. Nature communications. 2015;6:7317. doi:10.1038/ncomms8317

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

Palsson-McDermott EM, Curtis AM, Goel G, et al. Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages. Cell metabolism. 2015;21(2):347. doi:10.1016/j.cmet.2015.01.017

Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.

Nagiec MM, Skepner AP, Negri J, et al. Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. PLoS One. 2015;10(3):e0120295. doi:10.1371/journal.pone.0120295

Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.

Lennerz BS, Vafai SB, Delaney NF, et al. Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans. Mol Genet Metab. 2015;114(1):73-9. doi:10.1016/j.ymgme.2014.11.010

HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.

Carroll JB, Deik A, Fossale E, et al. HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation. PLoS One. 2015;10(8):e0134465. doi:10.1371/journal.pone.0134465