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Proteomics Platform

Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging.

Hung V, Zou P, Rhee HW, et al. Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging. Mol Cell. 2014;55(2):332-41. doi:10.1016/j.molcel.2014.06.003

CPTAC Assay Portal: a repository of targeted proteomic assays.

Whiteaker JR, Halusa GN, Hoofnagle AN, et al. CPTAC Assay Portal: a repository of targeted proteomic assays. Nat Methods. 2014;11(7):703-4. doi:10.1038/nmeth.3002

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Lassen KG, Kuballa P, Conway KL, et al. Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc Natl Acad Sci U S A. 2014;111(21):7741-6. doi:10.1073/pnas.1407001111

Mycobacterial Esx-3 requires multiple components for iron acquisition.

Siegrist S, Steigedal M, Ahmad R, et al. Mycobacterial Esx-3 requires multiple components for iron acquisition. MBio. 2014;5(3):e01073-14. doi:10.1128/mBio.01073-14

High reliability in respiratory rate assessment in children with respiratory symptomatology in a rural area in Mozambique.

Lanaspa M, Valim C, Acácio S, et al. High reliability in respiratory rate assessment in children with respiratory symptomatology in a rural area in Mozambique. J Trop Pediatr. 2014;60(2):93-8. doi:10.1093/tropej/fmt081

Simplified and efficient quantification of low-abundance proteins at very high multiplex via targeted mass spectrometry.

Burgess MW, Keshishian H, Mani DR, Gillette MA, Carr SA. Simplified and efficient quantification of low-abundance proteins at very high multiplex via targeted mass spectrometry. Mol Cell Proteomics. 2014;13(4):1137-49. doi:10.1074/mcp.M113.034660

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.

Naba A, Clauser K, Lamar J, Carr S, Hynes RO. Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters. eLife. 2014;3:e01308.

Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach.

Carr SA, Abbatiello SE, Ackermann BL, et al. Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach. Mol Cell Proteomics. 2014;13(3):907-17. doi:10.1074/mcp.M113.036095

Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins.

Kennedy JJ, Abbatiello SE, Kim K, et al. Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins. Nat Methods. 2014;11(2):149-55. doi:10.1038/nmeth.2763

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.

Krönke J, Udeshi ND, Narla A, et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science. 2014;343(6168):301-5. doi:10.1126/science.1244851