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Proteomics Platform

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.

Hsu YHH, Pintacuda G, Liu R, et al. Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia. iScience. 2023;26(5):106701. doi:10.1016/j.isci.2023.106701

Proteomic profiling of extracellular matrix components from patient metastases identifies consistently elevated proteins for developing nanobodies that target primary tumors and metastases.

Jailkhani N, Clauser KR, Mak HH, et al. Proteomic profiling of extracellular matrix components from patient metastases identifies consistently elevated proteins for developing nanobodies that target primary tumors and metastases. Cancer research. 2023. doi:10.1158/0008-5472.CAN-22-1532

Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells.

Lee SY, Cheah JS, Zhao B, et al. Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.09.531939

Chromatin regulator SMARCAL1 modulates cellular lipid metabolism.

Nagai TH, Hartigan C, Mizoguchi T, et al. Chromatin regulator SMARCAL1 modulates cellular lipid metabolism. Communications biology. 2023;6(1):1298. doi:10.1038/s42003-023-05665-6

ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer.

Mota I, Patrucco E, Mastini C, et al. ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer. Nature cancer. 2023. doi:10.1038/s43018-023-00591-2

Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset.

Mansur A, Joseph R, Kim E, et al. Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset. eLife. 2023;12. doi:10.7554/eLife.81966

Dynamic mapping of proteome trafficking within and between living cells by TransitID.

Xu W, Cheah J, Xu C, et al. Dynamic mapping of proteome trafficking within and between living cells by TransitID. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.02.07.527548

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling.

Gentili M, Liu B, Papanastasiou M, et al. ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature communications. 2023;14(1):611. doi:10.1038/s41467-023-36132-9

An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity.

Ctortecka C, Hartlmayr D, Seth A, et al. An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity. Molecular & cellular proteomics : MCP. 2023:100665. doi:10.1016/j.mcpro.2023.100665

The HLA-II immunopeptidome of SARS-CoV-2.

Weingarten-Gabbay S, Chen DY, Sarkizova S, et al. The HLA-II immunopeptidome of SARS-CoV-2. Cell reports. 2023;43(1):113596. doi:10.1016/j.celrep.2023.113596