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Proteomics Platform

Sensitive detection of cancer antigens enabled by user-defined peptide libraries.

Manakongtreecheep K, Ctortecka C, Correa-Medero LO, et al. Sensitive detection of cancer antigens enabled by user-defined peptide libraries. Nature biotechnology. 2026. doi:10.1038/s41587-026-03003-9

Nano-scaled, fully automated hydrogen/deuterium exchange for analysis of macromolecular assemblies reaching the MDa scale.

Raval S, Shi Y, Morriss JW, et al. Nano-scaled, fully automated hydrogen/deuterium exchange for analysis of macromolecular assemblies reaching the MDa scale. Molecular & cellular proteomics : MCP. 2026:101519. doi:10.1016/j.mcpro.2026.101519

Mass spectrometry-based profiling of single-cell histone post-translational modifications to dissect chromatin heterogeneity.

Cutler R, Corveleyn L, Ctortecka C, et al. Mass spectrometry-based profiling of single-cell histone post-translational modifications to dissect chromatin heterogeneity. Nature communications. 2025;16(1):11100. doi:10.1038/s41467-025-66031-0

Targeting of HIF2-driven cachexia in kidney cancer.

Abu-Remaileh M, Stransky LA, Bhalerao N, et al. Targeting of HIF2-driven cachexia in kidney cancer. Nature medicine. 2025. doi:10.1038/s41591-025-04054-2

Integrative proteogenomics and forward genetics reveals a novel mitotic vulnerability in triple-negative breast cancer.

Neill NJ, Satpathy S, Krug K, et al. Integrative proteogenomics and forward genetics reveals a novel mitotic vulnerability in triple-negative breast cancer. Cancer discovery. 2025. doi:10.1158/2159-8290.CD-23-1173

Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures.

Satpathy S, Clark NM, Chen YJ, et al. Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures. Cancer cell. 2025. doi:10.1016/j.ccell.2025.07.011

High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissues.

Haines M, Thorup JR, Gohsman S, et al. High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissues. Molecular & cellular proteomics : MCP. 2025:101044. doi:10.1016/j.mcpro.2025.101044

Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy.

Lee SY, Roh H, Gonzalez-Perez D, et al. Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.29.620861

Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway.

Xiao L, Pi X, Goss AC, et al. Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway. Science advances. 2024;10(38):eadp2221. doi:10.1126/sciadv.adp2221

High-quality peptide evidence for annotating non-canonical open reading frames as human proteins.

Deutsch EW, Kok LW, Mudge JM, et al. High-quality peptide evidence for annotating non-canonical open reading frames as human proteins. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.09.09.612016