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Stanley Center for Psychiatric Research

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk.

Reshef YA, Finucane HK, Kelley DR, et al. Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk. Nat Genet. 2018;50(10):1483-1493. doi:10.1038/s41588-018-0196-7

Gene therapy for neurological disorders: progress and prospects.

Deverman BE, Ravina BM, Bankiewicz KS, Paul SM, W Y Sah D. Gene therapy for neurological disorders: progress and prospects. Nat Rev Drug Discov. 2018;17(10):767. doi:10.1038/nrd.2018.158

The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families.

Hiekkala ME, Vuola P, Artto V, et al. The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families. Cephalalgia. 2018;38(12):1849-1863. doi:10.1177/0333102418761041

Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.

Risher C, Kim N, Koh S, et al. Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. J Cell Biol. 2018;217(10):3747-3765. doi:10.1083/jcb.201802057

New tricks for an ancient system: Physiological and pathological roles of complement in the CNS.

Tenner AJ, Stevens B, Woodruff TM. New tricks for an ancient system: Physiological and pathological roles of complement in the CNS. Mol Immunol. 2018;102:3-13. doi:10.1016/j.molimm.2018.06.264

Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis.

Velthorst E, Froudist-Walsh S, Stahl E, et al. Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis. Transl Psychiatry. 2018;8(1):204. doi:10.1038/s41398-018-0229-0

De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis.

Wang S, Mandell JD, Kumar Y, et al. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis. Cell Rep. 2018;24(13):3441-3454.e12. doi:10.1016/j.celrep.2018.08.082

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls.

Pettersson E, Lichtenstein P, Larsson H, et al. Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. Psychol Med. 2018:1-8. doi:10.1017/S0033291718002039

Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells.

Darnell M, O’Neil A, Mao A, Gu L, Rubin LL, Mooney DJ. Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells. Proc Natl Acad Sci U S A. 2018;115(36):E8368-E8377. doi:10.1073/pnas.1802568115

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study.

Yang HS, Yu L, White CC, et al. Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study. Lancet Neurol. 2018;17(9):773-781. doi:10.1016/S1474-4422(18)30251-5