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Stanley Center for Psychiatric Research

Genetics Sheds New Light on Congenital Hydrocephalus Biology.

Lal D, Palotie A. Genetics Sheds New Light on Congenital Hydrocephalus Biology. Neuron. 2018;99(2):246-247. doi:10.1016/j.neuron.2018.07.008

Layer I Interneurons Sharpen Sensory Maps during Neonatal Development.

Che A, Babij R, Iannone AF, et al. Layer I Interneurons Sharpen Sensory Maps during Neonatal Development. Neuron. 2018;99(1):98-116.e7. doi:10.1016/j.neuron.2018.06.002

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function.

Amal H, Barak B, Bhat V, et al. Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function. Mol Psychiatry. 2018. doi:10.1038/s41380-018-0113-6

Viral Strategies for Targeting the Central and Peripheral Nervous Systems.

Bedbrook CN, Deverman BE, Gradinaru V. Viral Strategies for Targeting the Central and Peripheral Nervous Systems. Annu Rev Neurosci. 2018;41:323-348. doi:10.1146/annurev-neuro-080317-062048

Age at first birth in women is genetically associated with increased risk of schizophrenia.

Ni G, Gratten J, Wray NR, Lee SH, Schizophrenia Working Group of the Psychiatric Genomics Consortium. Age at first birth in women is genetically associated with increased risk of schizophrenia. Sci Rep. 2018;8(1):10168. doi:10.1038/s41598-018-28160-z

Toward Precision Medicine for Neurological and Neuropsychiatric Disorders.

Gibbs RM, Lipnick S, Bateman JW, et al. Toward Precision Medicine for Neurological and Neuropsychiatric Disorders. Cell Stem Cell. 2018;23(1):21-24. doi:10.1016/j.stem.2018.05.019

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.

Mordes DA, Prudencio M, Goodman LD, et al. Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathol Commun. 2018;6(1):55. doi:10.1186/s40478-018-0555-8

Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.

Porter NJ, Wagner FF, Christianson DW. Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry. 2018;57(26):3916-3924. doi:10.1021/acs.biochem.8b00367

Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes.

Rodriguez-Muela N, Parkhitko A, Grass T, et al. Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes. J Clin Invest. 2018;128(7):3008-3023. doi:10.1172/JCI95231

Prevalence of rearrangements in the 22q11.2 region and population-based risk of neuropsychiatric and developmental disorders in a Danish population: a case-cohort study.

Olsen L, Sparsø T, Weinsheimer SM, et al. Prevalence of rearrangements in the 22q11.2 region and population-based risk of neuropsychiatric and developmental disorders in a Danish population: a case-cohort study. Lancet Psychiatry. 2018;5(7):573-580. doi:10.1016/S2215-0366(18)30168-8