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Stanley Center for Psychiatric Research

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function.

Amal H, Barak B, Bhat V, et al. Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function. Mol Psychiatry. 2018. doi:10.1038/s41380-018-0113-6

Viral Strategies for Targeting the Central and Peripheral Nervous Systems.

Bedbrook CN, Deverman BE, Gradinaru V. Viral Strategies for Targeting the Central and Peripheral Nervous Systems. Annu Rev Neurosci. 2018;41:323-348. doi:10.1146/annurev-neuro-080317-062048

Toward Precision Medicine for Neurological and Neuropsychiatric Disorders.

Gibbs RM, Lipnick S, Bateman JW, et al. Toward Precision Medicine for Neurological and Neuropsychiatric Disorders. Cell Stem Cell. 2018;23(1):21-24. doi:10.1016/j.stem.2018.05.019

Age at first birth in women is genetically associated with increased risk of schizophrenia.

Ni G, Gratten J, Wray NR, Lee SH, Schizophrenia Working Group of the Psychiatric Genomics Consortium. Age at first birth in women is genetically associated with increased risk of schizophrenia. Sci Rep. 2018;8(1):10168. doi:10.1038/s41598-018-28160-z

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.

Mordes DA, Prudencio M, Goodman LD, et al. Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathol Commun. 2018;6(1):55. doi:10.1186/s40478-018-0555-8

Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.

Porter NJ, Wagner FF, Christianson DW. Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry. 2018;57(26):3916-3924. doi:10.1021/acs.biochem.8b00367

Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes.

Rodriguez-Muela N, Parkhitko A, Grass T, et al. Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes. J Clin Invest. 2018;128(7):3008-3023. doi:10.1172/JCI95231

Depressive Symptoms, Antidepressant Use, and Hypertension in Young Adulthood.

Crookes DM, Demmer RT, Keyes KM, Koenen KC, Suglia SF. Depressive Symptoms, Antidepressant Use, and Hypertension in Young Adulthood. Epidemiology. 2018;29(4):547-555. doi:10.1097/EDE.0000000000000840

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits.

Hormozdiari F, Gazal S, van de Geijn B, et al. Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. Nat Genet. 2018;50(7):1041-1047. doi:10.1038/s41588-018-0148-2

Progress in Understanding and Treating SCN2A-Mediated Disorders.

Sanders SJ, Campbell AJ, Cottrell JR, et al. Progress in Understanding and Treating SCN2A-Mediated Disorders. Trends Neurosci. 2018;41(7):442-456. doi:10.1016/j.tins.2018.03.011