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Obesity

Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data.

Costanzo MC, Akolkar B, Claussnitzer M, et al. Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data. Diabetes. 2025. doi:10.2337/db25-0042

Variant-to-function approaches for adipose tissue: Insights into cardiometabolic disorders.

Metz S, Belanich JR, Claussnitzer M, Kilpeläinen TO. Variant-to-function approaches for adipose tissue: Insights into cardiometabolic disorders. Cell genomics. 2025:100844. doi:10.1016/j.xgen.2025.100844

Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue.

Emont MP, Essene AL, Gulko A, et al. Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue. Molecular metabolism. 2025:102126. doi:10.1016/j.molmet.2025.102126

Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease.

Yoshiji S, Lu T, Butler-Laporte G, et al. Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease. Nature genetics. 2025. doi:10.1038/s41588-024-02052-7

Light-responsive adipose-hypothalamus axis controls metabolic regulation.

Tsuji T, Tolstikov V, Zhang Y, et al. Light-responsive adipose-hypothalamus axis controls metabolic regulation. Nature communications. 2024;15(1):6768. doi:10.1038/s41467-024-50866-0

Associations between phenotypes of childhood and adolescent obesity and incident hypertension in young adulthood.

St Fleur RG, Tanofsky-Kraff M, Yanovski JA, et al. Associations between phenotypes of childhood and adolescent obesity and incident hypertension in young adulthood. International journal of obesity (2005). 2024. doi:10.1038/s41366-024-01700-6

BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis.

Verkerke ARP, Wang D, Yoshida N, et al. BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis. Cell. 2024;187(10):2359-2374.e18. doi:10.1016/j.cell.2024.03.030

Control of lipolysis by a population of oxytocinergic sympathetic neurons.

Li E, Wang L, Wang D, et al. Control of lipolysis by a population of oxytocinergic sympathetic neurons. Nature. 2024;625(7993):175-180. doi:10.1038/s41586-023-06830-x

Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice.

Lee J, Wellenstein K, Rahnavard A, et al. Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(28):e2318691121. doi:10.1073/pnas.2318691121

Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.

Yan S, Santoro A, Niphakis MJ, et al. Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels. Nature communications. 2024;15(1):4605. doi:10.1038/s41467-024-48220-5