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Obesity

A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

Wang L, Sinnott-Armstrong N, Wagschal A, et al. A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 2020;183(3):684-701.e14. doi:10.1016/j.cell.2020.09.017

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

Pulit SL, Stoneman C, Morris AP, et al. Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Hum Mol Genet. 2019;28(1):166-174. doi:10.1093/hmg/ddy327

Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain.

Geidenstam N, Hsu YHH, Astley CM, et al. Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain. PloS one. 2019;14(9):e0222445. doi:10.1371/journal.pone.0222445

Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity.

De Rosa MC, Chesi A, McCormack S, et al. Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity. The Journal of clinical endocrinology and metabolism. 2019;104(7):2961-2970. doi:10.1210/jc.2018-02657

Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Rosen ED, Kaestner KH, Natarajan R, et al. Epigenetics and Epigenomics: Implications for Diabetes and Obesity. Diabetes. 2018;67(10):1923-1931. doi:10.2337/db18-0537

Accumulation of succinate controls activation of adipose tissue thermogenesis.

Mills EL, Pierce KA, Jedrychowski MP, et al. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018;560(7716):102-106. doi:10.1038/s41586-018-0353-2

GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity.

Speakman JR, Loos RJF, O’Rahilly S, Hirschhorn JN, Allison DB. GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity. Int J Obes (Lond). 2018;42(8):1524-1531. doi:10.1038/s41366-018-0147-5

Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.

Roh HC, T Y Tsai L, Shao M, et al. Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab. 2018;27(5):1121-1137.e5. doi:10.1016/j.cmet.2018.03.005

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry.

Yengo L, Sidorenko J, Kemper KE, et al. Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Human molecular genetics. 2018;27(20):3641-3649. doi:10.1093/hmg/ddy271

Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity.

Astley CM, Todd JN, Salem RM, et al. Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity. Clin Chem. 2018;64(1):192-200. doi:10.1373/clinchem.2017.280727