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Obesity

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.

Oguri Y, Shinoda K, Kim H, et al. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020;182(3):563-577.e20. doi:10.1016/j.cell.2020.06.021

Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity.

De Rosa MC, Chesi A, McCormack S, et al. Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity. The Journal of clinical endocrinology and metabolism. 2019;104(7):2961-2970. doi:10.1210/jc.2018-02657

Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain.

Geidenstam N, Hsu YHH, Astley CM, et al. Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain. PloS one. 2019;14(9):e0222445. doi:10.1371/journal.pone.0222445

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

Pulit SL, Stoneman C, Morris AP, et al. Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Hum Mol Genet. 2019;28(1):166-174. doi:10.1093/hmg/ddy327

Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Rosen ED, Kaestner KH, Natarajan R, et al. Epigenetics and Epigenomics: Implications for Diabetes and Obesity. Diabetes. 2018;67(10):1923-1931. doi:10.2337/db18-0537

GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity.

Speakman JR, Loos RJF, O’Rahilly S, Hirschhorn JN, Allison DB. GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity. Int J Obes (Lond). 2018;42(8):1524-1531. doi:10.1038/s41366-018-0147-5

Accumulation of succinate controls activation of adipose tissue thermogenesis.

Mills EL, Pierce KA, Jedrychowski MP, et al. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018;560(7716):102-106. doi:10.1038/s41586-018-0353-2

Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.

Roh HC, T Y Tsai L, Shao M, et al. Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab. 2018;27(5):1121-1137.e5. doi:10.1016/j.cmet.2018.03.005

Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity.

Astley CM, Todd JN, Salem RM, et al. Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity. Clin Chem. 2018;64(1):192-200. doi:10.1373/clinchem.2017.280727

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Turcot V, Lu Y, Highland HM, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018;50(1):26-41. doi:10.1038/s41588-017-0011-x