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Obesity

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming.

Holman CD, Sakers AP, Calhoun RP, et al. Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming. eLife. 2024;12. doi:10.7554/eLife.87756

Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue.

Wang CH, Tsuji T, Wu LH, et al. Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. Nature communications. 2024;15(1):7215. doi:10.1038/s41467-024-51579-0

An integrative framework to prioritize genes in more than 500 loci associated with body mass index.

Hemerich D, Svenstrup V, Obrero VD, et al. An integrative framework to prioritize genes in more than 500 loci associated with body mass index. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.04.016

Impaired adipocyte SLC7A10 promotes lipid storage in association with insulin resistance and altered BCAA metabolism.

Jersin R Å, Tallapragada DSP, Skartveit L, et al. Impaired adipocyte SLC7A10 promotes lipid storage in association with insulin resistance and altered BCAA metabolism. The Journal of clinical endocrinology and metabolism. 2023. doi:10.1210/clinem/dgad148

Phenotyping children and adolescents with obesity using behavioral, psychological, and familial data.

St Fleur RG, Tanofsky-Kraff M, Yanovski JA, Horton NJ, Hirschhorn JN, Field AE. Phenotyping children and adolescents with obesity using behavioral, psychological, and familial data. Obesity (Silver Spring, Md.). 2023;31(12):3016-3024. doi:10.1002/oby.23893

Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover.

Huang M, Claussnitzer M, Saadat A, Coral DE, Kalamajski S, Franks PW. Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover. Diabetologia. 2023. doi:10.1007/s00125-023-05915-6

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Wieder N, Fried J, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell metabolism. 2023. doi:10.1016/j.cmet.2023.03.018

Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome.

Zhu J, Eliasen AU, Aris IM, et al. Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome. The Journal of clinical endocrinology and metabolism. 2023. doi:10.1210/clinem/dgad533

A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.

Glunk V, Laber S, Sinnott-Armstrong N, et al. A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes. Nature metabolism. 2023;5(5):861-879. doi:10.1038/s42255-023-00807-w

Genetics of sexually dimorphic adipose distribution in humans.

Hansen GT, Sobreira DR, Weber ZT, et al. Genetics of sexually dimorphic adipose distribution in humans. Nature genetics. 2023;55(3):461-470. doi:10.1038/s41588-023-01306-0